Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.73 |
| ▸ | HPGD | P15428 | 1/20 | 0.73 |
| ▸ | RAB9A | P51151 | 1/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.73 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2424631 | 0.87 | NPC1 (0.96) | NPC1HPGDRAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL29417850 | 0.87 | NPC1 (0.96) | NPC1HPGDRAB9ASMN1; SMN2NPSR1 | |
| Formaldehyde SCHEMBL27861058 | 0.82 | NPC1 (0.87) | NPC1HPGDRAB9ASMN1; SMN2CYP11B2 | |
| SCHEMBL29546679 | 0.75 | NPC1 (0.55) | NPC1HPGDRAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL7512518 | 0.74 | NPC1 (0.67) | NPC1HPGDRAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL2428264 | 0.71 | NPC1 (0.61) | NPC1HPGDRAB9ASMN1; SMN2CYP11B2 | |
| SCHEMBL29547185 | 0.70 | NPC1 (0.53) | NPC1HPGDRAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL2425683 | 0.65 | RAB9A (0.57) | NPC1HPGDRAB9ASMN1; SMN2CYP11B2 | |
| SCHEMBL904938 | 0.65 | NPC1 (0.55) | NPC1HPGDRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL2013877 | 0.65 | NPC1 (0.55) | NPC1HPGDRAB9ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104837832-B | GDF-8 inhibitors | 里格尔药品股份有限公司 | 2019-04-26 | — | — | CN | claimed |
| CN-104837832-A | GDF-8 inhibitors | RIGEL PHARMACEUTICALS INC | 2015-08-12 | — | — | CN | claimed |
| CN-104837832-B | GDF-8 inhibitors | 里格尔药品股份有限公司 | 2019-04-26 | — | — | CN | disclosed |
| CN-106536507-A | 2,3-disubstituted pyridine compounds as TGF-beta inhibitors and methods of use | 里格尔药品股份有限公司 | 2017-03-22 | — | — | CN | disclosed |
| CN-104837832-A | GDF-8 inhibitors | RIGEL PHARMACEUTICALS INC | 2015-08-12 | — | — | CN | disclosed |