Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.51 |
| ▸ | XDH | P47989 | 5/20 | 0.48 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | PI4KA | P42356 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.43 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28018886 | 0.81 | MKNK1 (0.55) | MKNK1MKNK2CYP11B2 | |
| SCHEMBL28425063 | 0.81 | CYP3A4 (0.46) | MKNK1MKNK2XDHPIK3C3CYP11B2 | |
| SCHEMBL17810015 | 0.78 | HDAC1 (0.59) | MKNK1MKNK2XDHCDK7PIK3CD | |
| SCHEMBL6257044 | 0.77 | PLK1 (0.66) | PLK1 | |
| SCHEMBL30147578 | 0.77 | PLK1 (0.66) | PLK1 | |
| SCHEMBL23977180 | 0.77 | SCN10A (0.67) | MKNK1MKNK2XDHPIK3CDPIK3CA | |
| SCHEMBL24151477 | 0.76 | PTPN1 (0.50) | MKNK1MKNK2CDK7DYRK1AGSK3B | |
| SCHEMBL17806746 | 0.74 | MKNK1 (0.52) | MKNK1MKNK2XDHCDK7PIK3CD | |
| SCHEMBL5909485 | 0.73 | RAF1 (0.53) | MKNK1MKNK2PLK1 | |
| SCHEMBL29812385 | 0.72 | PLK1 (0.59) | MKNK1MKNK2DYRK1APLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104837832-A | GDF-8 inhibitors | RIGEL PHARMACEUTICALS INC | 2015-08-12 | — | — | CN | claimed |
| CN-104837832-A | GDF-8 inhibitors | RIGEL PHARMACEUTICALS INC | 2015-08-12 | — | — | CN | disclosed |