Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.59 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.59 |
| ▸ | SCN10A | Q9Y5Y9 | 5/20 | 0.57 |
| ▸ | XDH | P47989 | 3/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | CDK7 | P50613 | 1/20 | 0.49 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | PI4KA | P42356 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.47 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23977180 | 0.86 | SCN10A (0.67) | CHRNA7SCN10AXDHMKNK1MKNK2 | |
| SCHEMBL8111416 | 0.83 | HDAC1 (0.55) | HDAC1CHRNA7SCN10AXDHKCNH2 | |
| SCHEMBL17806746 | 0.83 | MKNK1 (0.52) | HDAC1SCN10AXDHMKNK1MKNK2 | |
| SCHEMBL14210413 | 0.81 | MMP13 (0.53) | HDAC1MKNK1MKNK2CNR1 | |
| SCHEMBL12647206 | 0.80 | MKNK1 (0.69) | HDAC1CHRNA7SCN10AMKNK1MKNK2 | |
| SCHEMBL10274534 | 0.79 | HCAR2 (0.62) | MKNK1MKNK2PTGS2RAF1 | |
| SCHEMBL16574182 | 0.79 | MMP13 (0.69) | HDAC1MKNK1MKNK2CNR1 | |
| SCHEMBL5909485 | 0.78 | RAF1 (0.53) | MKNK1MKNK2PTGS2RAF1 | |
| SCHEMBL28019347 | 0.78 | MKNK1 (0.51) | SCN10AXDHMKNK1MKNK2CDK7 | |
| SCHEMBL6014132 | 0.77 | MMP13 (0.67) | XDHPTGS2RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160158207-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160158207-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | EP300, HDAC1, HDAC10 | HDAC1 2/4885CHRNA7 2134/4885SCN10A 1197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.