Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.43 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15639275 | 0.91 | ATR (0.47) | ALDH1A1CLK4CYP2C19HIF1ATSHR | |
| SCHEMBL15638089 | 0.87 | CYP2C19 (0.47) | ALDH1A1CLK4CYP2C19HIF1ATSHR | |
| SCHEMBL15638254 | 0.82 | PIK3CA (0.50) | ALDH1A1CLK4CYP2C19HIF1ATSHR | |
| SCHEMBL15637943 | 0.82 | ATR (0.49) | ALDH1A1CLK4CYP2C19HIF1ATSHR | |
| SCHEMBL15638373 | 0.82 | LRRK2 (0.42) | ALDH1A1CLK4CYP2C19HIF1ATSHR | |
| SCHEMBL15637551 | 0.76 | ALDH1A1 (0.66) | ALDH1A1CLK4CYP2C19HIF1ATSHR | |
| SCHEMBL28505160 | 0.74 | MAPKAPK2 (0.60) | ALDH1A1CLK4HIF1AMAPK1CYP1A2 | |
| SCHEMBL28019362 | 0.72 | TGFBR1 (0.64) | ALDH1A1CYP2C19CYP1A2CYP3A4TGFBR1 | |
| SCHEMBL15638230 | 0.72 | CLK4 (0.67) | ALDH1A1CLK4CYP2C19HIF1ATSHR | |
| SCHEMBL20392700 | 0.71 | ADORA2A (0.48) | ALDH1A1TSHRLMNANCF1METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104837832-B | GDF-8 inhibitors | 里格尔药品股份有限公司 | 2019-04-26 | — | — | CN | claimed |
| CN-104837832-A | GDF-8 inhibitors | RIGEL PHARMACEUTICALS INC | 2015-08-12 | — | — | CN | claimed |
| CN-104837832-B | GDF-8 inhibitors | 里格尔药品股份有限公司 | 2019-04-26 | — | — | CN | disclosed |
| CN-106536507-A | 2,3-disubstituted pyridine compounds as TGF-beta inhibitors and methods of use | 里格尔药品股份有限公司 | 2017-03-22 | — | — | CN | disclosed |
| CN-104837832-A | GDF-8 inhibitors | RIGEL PHARMACEUTICALS INC | 2015-08-12 | — | — | CN | disclosed |