Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 3/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.39 |
| ▸ | CDK9 | P50750 | 3/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15638546 | 0.83 | FEN1 (0.49) | FEN1CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL6581932 | 0.79 | MAPK14 (0.51) | FEN1CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL28018889 | 0.73 | TGFBR1 (0.62) | CDK2CDK5PRKACACDC7TGFBR1 | |
| SCHEMBL27527497 | 0.72 | LOXL2 (0.41) | HSP90AA1HSP90AB1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL27892075 | 0.70 | CLK1 (0.50) | CCNT1CCNA2CDK2CDK9PDPK1 | |
| SCHEMBL21908761 | 0.70 | CDK5 (0.53) | FEN1CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL29889857 | 0.70 | CDK5 (0.53) | FEN1CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL28018884 | 0.70 | TGFBR1 (0.38) | FEN1HSP90AA1HSP90AB1KMOTGFBR1 | |
| SCHEMBL17177348 | 0.70 | MPL (0.43) | FEN1KMOTGFBR1DPP4 | |
| SCHEMBL18853922 | 0.69 | ALOX5AP (0.40) | FEN1HSP90AA1HSP90AB1TGFBR1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104837832-A | GDF-8 inhibitors | RIGEL PHARMACEUTICALS INC | 2015-08-12 | — | — | CN | disclosed |