Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 3/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.37 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | PTPRC | P08575 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | QPCT | Q16769 | 1/20 | 0.35 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28019408 | 0.91 | TRPV1 (0.39) | ACVR1TGFBR1TRPA1PRMT5WDR77 | |
| SCHEMBL28019403 | 0.87 | ACVR1 (0.42) | ACVR1TGFBR1PRMT5WDR77KMO | |
| SCHEMBL15639315 | 0.84 | KMO (0.46) | ACVR1TGFBR1PRMT5WDR77PIM1 | |
| SCHEMBL15637987 | 0.84 | MAPK14 (0.43) | ACVR1TGFBR1KMOCLK4ALDH1A1 | |
| SCHEMBL15638657 | 0.79 | IDO1 (0.42) | ACVR1TGFBR1KMO | |
| SCHEMBL15637769 | 0.77 | KMO (0.48) | ACVR1TGFBR1KMO | |
| SCHEMBL28019407 | 0.77 | ACVR1 (0.39) | ACVR1TGFBR1PRMT5WDR77PIM1 | |
| SCHEMBL15638472 | 0.76 | ACVR1 (0.39) | ACVR1TGFBR1PIM1PIM3PIM2 | |
| SCHEMBL15638787 | 0.75 | KMO (0.46) | ACVR1TGFBR1PRMT5WDR77PIM1 | |
| SCHEMBL15640109 | 0.74 | MAPK14 (0.43) | ACVR1TGFBR1KMOCLK4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104837832-A | GDF-8 inhibitors | RIGEL PHARMACEUTICALS INC | 2015-08-12 | — | — | CN | disclosed |