Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 2/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.36 |
| ▸ | QPCT | Q16769 | 1/20 | 0.36 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28019403 | 0.90 | ACVR1 (0.42) | ACVR1KMOPTGS1PTGS2L3MBTL1 | |
| SCHEMBL15640109 | 0.90 | MAPK14 (0.43) | ACVR1KMOPTGS1PTGS2TGFBR1 | |
| SCHEMBL28019408 | 0.87 | TRPV1 (0.39) | ACVR1KMOPTGS1PTGS2TGFBR1 | |
| SCHEMBL15638787 | 0.85 | KMO (0.46) | ACVR1KMOTGFBR1TDO2PRMT5 | |
| SCHEMBL15637987 | 0.80 | MAPK14 (0.43) | ACVR1KMOPTGS1PTGS2TGFBR1 | |
| SCHEMBL15640075 | 0.79 | ACVR1 (0.37) | ACVR1KMOTGFBR1QPCTQPCTL | |
| SCHEMBL28019404 | 0.77 | ACVR1 (0.41) | ACVR1KMOTGFBR1PRMT5WDR77 | |
| SCHEMBL15639315 | 0.76 | KMO (0.46) | ACVR1KMOTGFBR1PRMT5WDR77 | |
| SCHEMBL29638516 | 0.75 | PARP1 (0.54) | CHEK1PARP1PIM1RPS6KA3 | |
| SCHEMBL13003705 | 0.75 | PARP1 (0.54) | CHEK1PARP1PIM1RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104837832-A | GDF-8 inhibitors | RIGEL PHARMACEUTICALS INC | 2015-08-12 | — | — | CN | disclosed |