Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7749862 | 0.81 | KMT2A (0.46) | LMNAALDH1A1HPGDCYP2C9SMN1; SMN2 | |
| SCHEMBL4073041 | 0.79 | ALDH1A1 (0.62) | LMNAALDH1A1HPGDCYP2C9SMN1; SMN2 | |
| SCHEMBL294028 | 0.77 | MAOB (0.43) | LMNAKDM4EALDH1A1SMN1; SMN2CYP2C19 | |
| SCHEMBL6582849 | 0.77 | MAOB (0.43) | LMNAALDH1A1HPGDCYP2C9SMN1; SMN2 | |
| SCHEMBL27593026 | 0.77 | KMT2A (0.57) | LMNAKDM4EALDH1A1HPGDCYP2C9 | |
| SCHEMBL18343734 | 0.75 | ALDH1A1 (0.46) | LMNAALDH1A1HPGDCYP2C9SMN1; SMN2 | |
| SCHEMBL4324015 | 0.74 | L3MBTL1 (0.59) | LMNAALDH1A1HPGDSMN1; SMN2TDP1 | |
| SCHEMBL15229237 | 0.74 | NPC1 (0.59) | LMNAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4334225 | 0.73 | ALDH1A1 (0.40) | LMNAALDH1A1HPGDCYP2C9SMN1; SMN2 | |
| SCHEMBL7250131 | 0.73 | KMT2A (0.63) | ALDH1A1SMN1; SMN2MMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104854124-A | Macrocyclic ketoamide immunoproteasome inhibitors | HOFFMANN LA ROCHE | 2015-08-19 | — | — | CN | disclosed |