Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRB1 | P17538 | 1/20 | 0.43 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.42 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12081860 | 1.00 | CTRB1 (0.43) | CTRB1P2RX4P2RX1P2RX3SMN1; SMN2 | |
| SCHEMBL12081753 | 1.00 | CTRB1 (0.43) | CTRB1P2RX4P2RX1P2RX3SMN1; SMN2 | |
| SCHEMBL2802050 | 0.94 | SMN1; SMN2 (0.40) | CTRB1P2RX4P2RX1P2RX3SMN1; SMN2 | |
| SCHEMBL12082089 | 0.84 | KLK7 (0.38) | ALDH1A1BCHE | |
| SCHEMBL2800249 | 0.84 | KLK7 (0.38) | ALDH1A1BCHE | |
| SCHEMBL12081802 | 0.84 | KLK7 (0.38) | ALDH1A1BCHE | |
| SCHEMBL2799647 | 0.84 | EPHX2 (0.38) | ALDH1A1FKBP1ABCHE | |
| SCHEMBL2800251 | 0.81 | KLK7 (0.38) | — | |
| SCHEMBL12081804 | 0.70 | ABCB1 (0.40) | HTR2CMEN1KMT2ABCHE | |
| SCHEMBL2802500 | 0.70 | ABCB1 (0.40) | HTR2CMEN1KMT2ABCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2172459-B1 | COMPOUND HAVING HYDANTOIN RING AND METHOD OF PRODUCING THE SAME | TOKUYAMA CORP (JP) | 2014-03-19 | — | — | EP | disclosed |
| US-8404860-B2 | Compound having hydantoin ring and method of producing the same | TOKUYAMA CORPORATION (JP) | 2013-03-26 | — | — | US | disclosed |
| US-20120289705-A1 | COMPOUND HAVING HYDANTOIN RING AND METHOD OF PRODUCING THE SAME | SHIIGI HIROFUMI (JP) | 2012-11-15 | — | — | US | disclosed |
| US-20120289705-A1 | COMPOUND HAVING HYDANTOIN RING AND METHOD OF PRODUCING THE SAME | SHIIGI HIROFUMI (JP) | 2012-11-15 | — | — | US | disclosed |
| US-8258313-B2 | Compound having hydantoin ring and method of producing the same | TOKUYAMA CORPORATION (JP) | 2012-09-04 | — | — | US | disclosed |
| US-8258313-B2 | Compound having hydantoin ring and method of producing the same | TOKUYAMA CORPORATION (JP) | 2012-09-04 | — | — | US | disclosed |
| US-20100184993-A1 | COMPOUND HAVING HYDANTOIN RING AND METHOD OF PRODUCING THE SAME | TOKUYAMA CORPORATION (JP) | 2010-07-22 | — | — | US | disclosed |
| US-20100184993-A1 | COMPOUND HAVING HYDANTOIN RING AND METHOD OF PRODUCING THE SAME | TOKUYAMA CORPORATION (JP) | 2010-07-22 | — | — | US | disclosed |
| EP-2172459-A1 | COMPOUND HAVING HYDANTOIN RING AND METHOD OF PRODUCING THE SAME | Tokuyama Corporation (JP) | 2010-04-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120289705-A1 | COMPOUND HAVING HYDANTOIN RING AND METHOD OF PRODUCING THE SAME | CASP14, CYP8B1, DDT | CTRB1 3130/4885P2RX4 1010/4885P2RX1 1614/4885 |
| US-20100184993-A1 | COMPOUND HAVING HYDANTOIN RING AND METHOD OF PRODUCING THE SAME | CASP14, CYP8B1, DDT | CTRB1 3130/4885P2RX4 1010/4885P2RX1 1614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.