CASP14 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL3347831	1.00	2/20
SCHEMBL3350907	1.00	2/20
SCHEMBL3346441	0.75	2/20
SCHEMBL3348177	0.75	2/20
SCHEMBL3346602	0.70	2/20
SCHEMBL3346331	0.68	2/20
SCHEMBL5031260	0.58	2/20
SCHEMBL5029172	0.47	2/20
SCHEMBL14294391	0.47	2/20
SCHEMBL17219998	0.45	2/20
SCHEMBL5029195	0.43	2/20
SCHEMBL4841107	0.41	2/20
SCHEMBL18760597	0.41	2/20
SCHEMBL795592	0.38	2/20
SCHEMBL4898439	0.38	2/20
SCHEMBL3758852	1.00	1/20
SCHEMBL4074929	0.73	1/20
SCHEMBL13056961	0.69	1/20
SCHEMBL3755750	0.69	1/20
SCHEMBL3758053	0.69	1/20

Clinical trials — most relevant to CASP14 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Can Vitamin D Reduce Heart Muscle Damage After Bypass Surgery?	PHASE4	COMPLETED
Clinical Study Evaluating the Anticancer Effect of Pentoxiphylline in Patients With Metastatic Colorectal Cancer	PHASE4	UNKNOWN
Strategies to Reduce Organic Muscle Atrophy in the Intensive Care Unit	PHASE2/PHASE3	WITHDRAWN
Minocycline for the Treatment of Early-Phase Schizophrenia	PHASE3	COMPLETED
The Effect of Trimetazidine on the Clinical Outcome of Acute Ischemic Stroke Patients	PHASE3	COMPLETED
Disulfiram in Rheumatoid Arthritis	PHASE2	NOT_YET_RECRUITING
18F-CP18 Imaging Studies for Cancer Treatment With Birinapant	PHASE2	WITHDRAWN
Safety, Tolerability, and Treatment Effect of Belnacasan in Patients With COVID-19	PHASE2	COMPLETED
A Study of IDN-6556 in Subjects With Liver Cirrhosis	PHASE2	COMPLETED
Atorvastatin Calcium, Oligofructose-Enriched Inulin, or Sulindac in Preventing Cancer in Patients at Increased Risk of Developing Colorectal Neoplasia	PHASE2	COMPLETED
Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival	PHASE1	UNKNOWN
Dual-Targeting CAR-NK Cells for Recurrent/Progressive Glioblastoma and High-Grade Glioma	PHASE1	RECRUITING
Circulating Markers for Ischemic Heart Disease	nan	RECRUITING
Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure	nan	RECRUITING
Apoptosis Markers in Aggressive Periodontitis	nan	COMPLETED
Impact of CASP3 Gene in Chemoresistance	nan	NOT_YET_RECRUITING
Inflammasomes in Cell Death in FTMH, ERM, and RRD	nan	COMPLETED
Evaluation of Serum Gasdermin D Level As a Potential Biomarker of Disease Activity in Vitiligo Patients	nan	UNKNOWN
Role of Serum ADAM 17 (A Disintegrin And Metalloprotease 17) and Caspase 3 in Patients With Chronic Kidney Disease	nan	NOT_YET_RECRUITING
New Signaling Pathway Targeting Systemic Lupus Erythematosus	nan	UNKNOWN
Effect of Periodontal Treatment on Inflammasome Proteins in Periodontal Diseases	nan	UNKNOWN
Analysis of the Variation in Caspase-8 Availability and Cleavage in Oral Squamous Cell Carcinoma	nan	UNKNOWN
Evaluation of Inflammasome Gene Polymorphisms in Periodontitis Patients	nan	UNKNOWN
Characterization of Non-canonical Way in Inflammasome Monocytes of Patients With Severe Sepsis	nan	COMPLETED
High Dose Omega-3 Fatty Acids in the Treatment of Sport Related Concussions	nan	COMPLETED
The Effect of Vitamin E-coated Polysulfone Membrane on Oxidative Stress, Inflammation and Monocytes in Critically Ill Patients in CRRT	nan	UNKNOWN
Card14gene (rs34367357 ) Polymorphism in Egyptian Psoriatic and Psoriatic Arthritis Patient	nan	RECRUITING
Functional Pharmacogenomics of Childhood Acute Lymphoblastic Leukemia in Taiwan	nan	UNKNOWN
Neutrophils as Prognostic Factors in Granulomatosis With Polyangiitis (Formerly Named Wegener's Granulomatosis)	nan	COMPLETED
The Role of Pyroptosis in Chronic Venous Disease	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a CASP14 binder may also engage these)

Protein	Name	Similarity
O89094	—	0.998	O89094 →
Q9I9L7	—	0.986	Q9I9L7 →
P55867	—	0.981	P55867 →
P55865	—	0.980	P55865 →
Q9TZP5	—	0.976	Q9TZP5 →
Q98943	—	0.975	Q98943 →
Q504J1	—	0.973	Q504J1 →
Q9JHX4	—	0.970	Q9JHX4 →
CASP9	Caspase-9	0.970	landscape →
O89110	—	0.967	O89110 →
P55866	—	0.964	P55866 →
O02002	—	0.963	O02002 →
Q9XYF4	—	0.962	Q9XYF4 →
Q8C3Q9	—	0.960	Q8C3Q9 →
P49048	—	0.958	P49048 →
CASP2	Caspase-2	0.958	landscape →
A0A1D5PPP7	—	0.956	A0A1D5PPP7 →
Q9C8U6	—	0.956	Q9C8U6 →
P70343	—	0.955	P70343 →
Q3MHZ7	—	0.954	Q3MHZ7 →
Q8IRY7	—	0.954	Q8IRY7 →
Q60629	—	0.953	Q60629 →
P58875	—	0.953	P58875 →
Q92178	—	0.953	Q92178 →
Q8T4E1	—	0.953	Q8T4E1 →
Q9EQG7	—	0.953	Q9EQG7 →
Q68EH8	—	0.952	Q68EH8 →
B3DLB3	—	0.952	B3DLB3 →
CAPN9	Calpain-9	0.952	landscape →
P89116	—	0.952	P89116 →