Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5349811 | 0.87 | KDM4E (0.33) | KDM4EMEN1ALDH1A1MAPTHPGD | |
| Magnesium SCHEMBL6756894 | 0.86 | KDM4E (0.33) | KDM4EMEN1ALDH1A1MAPTHPGD | |
| Hydrochloric Acid SCHEMBL10875045 | 0.86 | KDM4E (0.33) | KDM4EMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL27274828 | 0.86 | KDM4E (0.33) | KDM4EMEN1ALDH1A1MAPTHPGD | |
| Hydrochloric Acid SCHEMBL27281219 | 0.84 | KDM4E (0.32) | KDM4EMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL27276294 | 0.82 | LMNA (0.31) | KDM4EMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL346179 | 0.75 | KDM4E (0.33) | KDM4EMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL27574664 | 0.73 | KDM4E (0.31) | KDM4EMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL28940893 | 0.71 | KDM4E (0.33) | KDM4EMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL28986086 | 0.71 | KDM4E (0.33) | KDM4EMEN1ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108310393-A | A kind of application of rifamycin-quinolizine ketone coupling molecule | 丹诺医药(苏州）有限公司 | 2018-07-24 | — | — | CN | claimed |
| CN-104710439-B | A kind of crystal formation I of rifamycin quinolizine ketone dual-target molecule and preparation method thereof | 丹诺医药(苏州）有限公司 | 2017-11-07 | — | — | CN | claimed |
| CN-106902116-A | A kind of new opplication of rifamycin quinolizine ketone dual-target molecule | 丹诺医药(苏州）有限公司 | 2017-06-30 | — | — | CN | claimed |
| CN-106822125-A | A kind of new application of rifamycin quinolizine ketone dual-target molecule | 丹诺医药(苏州）有限公司 | 2017-06-13 | — | — | CN | claimed |
| CN-104628745-B | A kind of fumarate of rifamycin quinolizine ketone dual-target molecule and preparation method thereof | 丹诺医药(苏州）有限公司 | 2017-03-08 | — | — | CN | claimed |
| CN-104710439-A | Crystal form I of rifamycin-quinolizidone double-drone molecule and preparation method of crystal form I | TENNOR THERAPEUTICS LTD | 2015-06-17 | — | — | CN | claimed |
| CN-104628745-A | Fumarate of rifamycin-quinolizidone dual-target molecule and preparation method thereof | TENNOR THERAPEUTICS LTD | 2015-05-20 | — | — | CN | claimed |
| CN-108017635-A | A kind of method of successive reaction synthesizing aryl benzoquinolizine ketone compounds | 黑龙江大学 | 2018-05-11 | — | — | CN | disclosed |