SCHEMBL346179

SCHEMBL346179

OC1=C2C=CC=CN2CC=C1

nearest known ligand 0.33

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.33
ALDH1A1 P00352 2/20 0.33
HPGD P15428 2/20 0.33
MEN1 O00255 1/20 0.33
MAPT P10636 1/20 0.33
CASP1 P29466 1/20 0.33
CASP7 P55210 1/20 0.33
KMT2A Q03164 1/20 0.33
POLB P06746 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29104904 0.75 KDM4E (0.33) KDM4EALDH1A1HPGDMEN1MAPT
SCHEMBL28986086 0.75 KDM4E (0.33) KDM4EALDH1A1HPGDMEN1MAPT
SCHEMBL6423807 0.75 ALDH1A1 (0.33) KDM4EALDH1A1HPGDMEN1MAPT
SCHEMBL5361791 0.75 KDM4E (0.33) KDM4EALDH1A1HPGDMEN1MAPT
SCHEMBL28020567 0.75 KDM4E (0.34) KDM4EALDH1A1HPGDMEN1MAPT
SCHEMBL5349811 0.73 KDM4E (0.33) KDM4EALDH1A1HPGDMEN1MAPT
SCHEMBL28940893 0.72 KDM4E (0.33) KDM4EALDH1A1HPGDMEN1MAPT
Magnesium SCHEMBL6756894 0.72 KDM4E (0.33) KDM4EALDH1A1HPGDMEN1MAPT
SCHEMBL27274828 0.72 KDM4E (0.33) KDM4EALDH1A1HPGDMEN1MAPT
Hydrochloric Acid SCHEMBL10875045 0.72 KDM4E (0.33) KDM4EALDH1A1HPGDMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1646528-A Polycyclic compounds as potent alpha2-adrenoceptor antagonists ORION CORP (FI) 2005-07-27 CN claimed
CN-119136667-A Ready-to-use plant treatment agent applicators, containers, and products UPL有限责任公司 2024-12-13 CN disclosed
CN-113573900-B Thermoplastic film and laminated glass 积水化学工业株式会社 2023-09-15 CN disclosed
EP-4214200-A1 LANCL LIGANDS Nimmune Biopharma, Inc. (US) 2023-07-26 EP disclosed
CN-113748109-B Lanthionine C-like protein 2 ligands, cells prepared with said ligands and therapies using said ligands 朗多生物制药股份有限公司 2023-07-21 CN disclosed
CN-116368133-A NLRX1 ligand 朗多生物制药股份有限公司 2023-06-30 CN disclosed
CN-113573890-B Thermoplastic film and laminated glass 积水化学工业株式会社 2023-06-06 CN disclosed
US-20230167083-A1 LANCL LIGANDS LANDOS BIOPHARMA, INC. (US) 2023-06-01 US disclosed
CN-113573889-B Thermoplastic film and laminated glass 积水化学工业株式会社 2023-05-26 CN disclosed
CN-115996697-A Cosmetic composition with improved penetration 莱雅公司 2023-04-21 CN disclosed
US-20060235002-A1 Novel physiologically active substance EISAI R&D MANAGEMENT CO., LTD. (JP) 2006-10-19 US disclosed
EP-1710244-A1 METHOD OF STABILIZING MACROLIDE COMPOUND Eisai R&D Management Co., Ltd. (JP) 2006-10-11 EP disclosed
EP-1705247-A1 DNA PARTICIPATING IN HYDROXYLATION OF MACROLIDE COMPOUND MERCIAN CORPORATION (JP) 2006-09-27 EP disclosed
US-20060009439-A1 Novel physiologically active substances MERCIAN CORPORATION (JP) 2006-01-12 US disclosed
US-20050245514-A1 Novel physiologically active substances MICROBIOPHARM JAPAN CO., LTD. (JP) 2005-11-03 US disclosed
US-20050227959-A1 Heterocyclic compound having oxime group EISAI CO., LTD. (JP) 2005-10-13 US disclosed
CN-1646528-A Polycyclic compounds as potent alpha2-adrenoceptor antagonists ORION CORP (FI) 2005-07-27 CN disclosed
EP-1548121-A1 NOVEL PHYSIOLOGICALLY ACTIVE SUBSTANCES MERCIAN CORPORATION (JP) 2005-06-29 EP disclosed
EP-1541570-A1 NOVEL PHYSIOLOGICALLY ACTIVE SUBSTANCE MERCIAN CORPORATION (JP) 2005-06-15 EP disclosed
EP-1508570-A1 NOVEL PHYSIOLGICALLY ACTIVE SUBSTANCES MERCIAN CORPORATION (JP) 2005-02-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050245514-A1 Novel physiologically active substances HIF1A, HIF1AN, VEGFA KDM4E 4239/4885ALDH1A1 133/4885HPGD 76/4885
US-20060009439-A1 Novel physiologically active substances HIF1A, HIF1AN, VEGFA KDM4E 3533/4885ALDH1A1 108/4885HPGD 82/4885
US-20060235002-A1 Novel physiologically active substance HIF1AN, HIF1A, VEGFA KDM4E 3844/4885ALDH1A1 119/4885HPGD 292/4885
US-20050227959-A1 Heterocyclic compound having oxime group STAT6, HRH4, HRH2 KDM4E 855/4885ALDH1A1 1391/4885HPGD 1479/4885
US-20230167083-A1 LANCL LIGANDS LANCL2, LANCL1, LCLAT1 KDM4E 3554/4885ALDH1A1 4156/4885HPGD 4822/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.