Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11378934 | 0.89 | NPC1 (0.53) | NPC1RAB9ALMNAMEN1KMT2A | |
| SCHEMBL6685647 | 0.83 | LMNA (0.52) | NPC1RAB9ALMNAKMT2ACA12 | |
| SCHEMBL8999155 | 0.81 | NPC1 (0.50) | NPC1RAB9ALMNAMEN1KMT2A | |
| SCHEMBL6685645 | 0.81 | LMNA (0.50) | NPC1RAB9ALMNAKMT2ACA12 | |
| SCHEMBL6253791 | 0.79 | NPC1 (0.50) | NPC1RAB9ALMNAMEN1KMT2A | |
| SCHEMBL4018145 | 0.78 | LMNA (0.56) | NPC1RAB9ALMNAMEN1KMT2A | |
| SCHEMBL2095210 | 0.77 | NPC1 (0.67) | NPC1RAB9AMEN1KMT2ACA12 | |
| SCHEMBL3058586 | 0.77 | GRIN2D (0.51) | NPC1RAB9ALMNACA12CA9 | |
| SCHEMBL3329308 | 0.75 | NPC1 (0.50) | NPC1RAB9ALMNAMEN1KMT2A | |
| SCHEMBL28908035 | 0.75 | NPC1 (0.50) | NPC1RAB9ALMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104736569-A | Compounds and methods for enhancing degradation of target proteins and other polypeptides by E3 ubiquitin ligase | UNIV YALE | 2015-06-24 | — | — | CN | disclosed |