Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | REN | P00797 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3328358 | 0.91 | LMNA (0.51) | LMNAALDH1A1NPSR1NPC1RAB9A | |
| SCHEMBL15762363 | 0.91 | LMNA (0.66) | LMNAALDH1A1NPSR1NPC1MEN1 | |
| SCHEMBL9574969 | 0.88 | HDAC1 (0.49) | LMNAALDH1A1NPSR1NPC1RAB9A | |
| SCHEMBL18154102 | 0.88 | HDAC1 (0.51) | LMNAALDH1A1NPSR1NPC1RAB9A | |
| SCHEMBL7517117 | 0.85 | CTSS (0.51) | LMNAALDH1A1NPSR1NPC1RAB9A | |
| SCHEMBL2188007 | 0.85 | HDAC6 (0.56) | LMNAREN | |
| SCHEMBL11378934 | 0.84 | NPC1 (0.53) | LMNAALDH1A1NPSR1NPC1RAB9A | |
| SCHEMBL2188566 | 0.84 | CNR2 (0.55) | LMNAALDH1A1REN | |
| SCHEMBL2095210 | 0.82 | NPC1 (0.67) | NPC1RAB9AMEN1KMT2ACA12 | |
| SCHEMBL18068879 | 0.81 | CETP (0.43) | LMNAALDH1A1NPSR1TDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074107-A2 | TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008057254-A2 | TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS | WYETH (US) | 2008-05-15 | — | — | WO | disclosed |