Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 3/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | GYS1 | P13807 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL288267 | 0.90 | P2RX7 (0.48) | P2RX7GAAPOLBKMT2ACYP2D6 | |
| SCHEMBL288266 | 0.90 | P2RX7 (0.48) | P2RX7GAAPOLBKMT2ACYP2D6 | |
| SCHEMBL28020910 | 0.81 | HCRTR1 (0.45) | KMT2AMEN1HCRTR2GYS1 | |
| SCHEMBL28270409 | 0.79 | P2RX7 (0.54) | P2RX7GAAKMT2ACYP2D6CYP2C19 | |
| SCHEMBL1162612 | 0.79 | P2RX7 (0.54) | P2RX7GAAKMT2ACYP2D6CYP2C19 | |
| SCHEMBL1162700 | 0.79 | P2RX7 (0.54) | P2RX7GAAKMT2ACYP2D6CYP2C19 | |
| SCHEMBL288978 | 0.77 | P2RX7 (0.55) | P2RX7KMT2ACYP2D6CYP2C19MEN1 | |
| SCHEMBL1611845 | 0.77 | P2RX7 (0.55) | P2RX7KMT2ACYP2D6CYP2C19MEN1 | |
| SCHEMBL30158802 | 0.76 | P2RX7 (0.39) | P2RX7GAAPOLBKMT2ACYP2D6 | |
| SCHEMBL28021326 | 0.76 | P2RX7 (0.57) | P2RX7GAAKMT2ACYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102482212-B | Carboxamide compounds and they are as the purposes of calpain inhibitor | ABBVIE (US) | 2015-08-26 | — | — | CN | claimed |
| CN-102482212-B | Carboxamide compounds and they are as the purposes of calpain inhibitor | ABBVIE (US) | 2015-08-26 | — | — | CN | disclosed |