Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 7/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | GYS1 | P13807 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL289561 | 0.90 | GYS1 (0.49) | HCRTR1HCRTR2KMT2AGYS1TDP1 | |
| SCHEMBL289122 | 0.90 | GYS1 (0.49) | HCRTR1HCRTR2KMT2AGYS1TDP1 | |
| SCHEMBL28020905 | 0.87 | HCRTR1 (0.53) | HCRTR1HCRTR2KMT2AGYS1KDM4E | |
| SCHEMBL28020907 | 0.81 | P2RX7 (0.45) | HCRTR2KMT2AGYS1MEN1 | |
| SCHEMBL288451 | 0.78 | GYS1 (0.58) | HCRTR1HCRTR2KMT2AGYS1SIGMAR1 | |
| SCHEMBL1612182 | 0.78 | GYS1 (0.58) | HCRTR1HCRTR2KMT2AGYS1SIGMAR1 | |
| SCHEMBL1162612 | 0.77 | P2RX7 (0.54) | KMT2A | |
| SCHEMBL1162700 | 0.77 | P2RX7 (0.54) | KMT2A | |
| SCHEMBL28270409 | 0.77 | P2RX7 (0.54) | KMT2A | |
| SCHEMBL16600994 | 0.77 | KMT2A (0.55) | HCRTR1HCRTR2KMT2AGYS1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102482212-B | Carboxamide compounds and they are as the purposes of calpain inhibitor | ABBVIE (US) | 2015-08-26 | — | — | CN | claimed |
| CN-102482212-B | Carboxamide compounds and they are as the purposes of calpain inhibitor | ABBVIE (US) | 2015-08-26 | — | — | CN | disclosed |