Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 14/20 | 0.54 |
| ▸ | KDR | P35968 | 14/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 12/20 | 0.54 |
| ▸ | KIT | P10721 | 11/20 | 0.51 |
| ▸ | CSF1R | P07333 | 2/20 | 0.51 |
| ▸ | FLT4 | P35916 | 2/20 | 0.51 |
| ▸ | CIT | O14578 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | HLA-A | P04439 | 1/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.50 |
| ▸ | FRK | P42685 | 1/20 | 0.50 |
| ▸ | CDK8 | P49336 | 1/20 | 0.50 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.50 |
| ▸ | STK3 | Q13188 | 1/20 | 0.50 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.50 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.50 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.50 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27625198 | 0.89 | KDR (0.57) | FLT1KDRPDGFRBKITCSF1R | |
| SCHEMBL28752805 | 0.83 | FLT1 (0.64) | FLT1KDRPDGFRBKITCSF1R | |
| SCHEMBL27625380 | 0.82 | KDR (0.65) | FLT1KDRPDGFRBKITCSF1R | |
| SCHEMBL905608 | 0.79 | KDR (0.80) | FLT1KDRPDGFRBKITCSF1R | |
| SCHEMBL28073018 | 0.76 | MAPT (0.64) | FLT1KDRPDGFRBKITCSF1R | |
| SCHEMBL27495149 | 0.76 | KDR (0.56) | FLT1KDRPDGFRBKITCSF1R | |
| SCHEMBL6607263 | 0.73 | KDR (0.73) | FLT1KDRPDGFRBKITCSF1R | |
| Picodralazine SCHEMBL2108694 | 0.73 | FLT1 (0.69) | FLT1KDRPDGFRBKITCSF1R | |
| SCHEMBL27511538 | 0.73 | FLT1 (0.60) | FLT1KDRPDGFRBKITCSF1R | |
| SCHEMBL24996489 | 0.71 | FLT1 (0.66) | FLT1KDRPDGFRBKITCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105492011-A | Therapeutic synergy of undesirable chemical compounds | BROWN DENNIS M | 2016-04-13 | — | — | CN | disclosed |
| CN-104797267-A | Method of treating tyrosine kinase inhibitor-resistant malignancies in patients with genetic polymorphism or AHI1 dysregulation or mutation using dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof | DEL MAR PHARMACEUTICALS | 2015-07-22 | — | — | CN | disclosed |