Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 12/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 10/20 | 0.55 |
| ▸ | FLT1 | P17948 | 10/20 | 0.55 |
| ▸ | KIT | P10721 | 9/20 | 0.55 |
| ▸ | CSF1R | P07333 | 2/20 | 0.48 |
| ▸ | FLT4 | P35916 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CIT | O14578 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | HLA-A | P04439 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL905597 | 0.78 | SHMT2 (0.78) | SHMT2KDRPDGFRBFLT1KIT | |
| SCHEMBL27625198 | 0.77 | KDR (0.57) | SHMT2KDRPDGFRBFLT1KIT | |
| SCHEMBL28021680 | 0.76 | FLT1 (0.54) | SHMT2KDRPDGFRBFLT1KIT | |
| SCHEMBL27625380 | 0.75 | KDR (0.65) | MAPTPOLBSHMT2KDRPDGFRB | |
| SCHEMBL28752805 | 0.74 | FLT1 (0.64) | SMN1; SMN2POLBSHMT2KDRPDGFRB | |
| SCHEMBL6609071 | 0.73 | KDR (0.75) | SHMT2KDRPDGFRBFLT1KIT | |
| SCHEMBL6778054 | 0.73 | SMN1; SMN2 (0.78) | MAPTSMN1; SMN2POLBALDH1A1NPC1 | |
| SCHEMBL6607263 | 0.73 | KDR (0.73) | KDRPDGFRBFLT1KITCSF1R | |
| SCHEMBL22680408 | 0.73 | KDR (0.83) | SHMT2KDRPDGFRBFLT1KIT | |
| SCHEMBL22680726 | 0.72 | SHMT2 (0.60) | POLBSHMT2KDRPDGFRBFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105579044-A | Use of dianhydrogalactitol and analogs and derivatives thereof for treating recurrent malignant glioma or progressive secondary brain tumor | DEL MAR PHARMACEUTICALS | 2016-05-11 | — | — | CN | disclosed |