Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 4/20 | 0.41 |
| ▸ | PLK4 | O00444 | 3/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | CDK1 | P06493 | 3/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | TYK2 | P29597 | 3/20 | 0.41 |
| ▸ | CLK2 | P49760 | 3/20 | 0.41 |
| ▸ | JAK3 | P52333 | 3/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.41 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.41 |
| ▸ | HIPK4 | Q8NE63 | 3/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.41 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.41 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.41 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28549341 | 0.95 | ALDH1A1 (0.45) | AURKBPLK4DAPK3JAK2CDK1 | |
| SCHEMBL28570220 | 0.86 | BPTF (0.38) | AURKBALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL28021591 | 0.85 | AURKB (0.51) | AURKBALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL28022051 | 0.85 | HRH4 (0.41) | AURKBMAPTBPTFTP53SMN1; SMN2 | |
| SCHEMBL2203178 | 0.84 | AURKB (0.53) | AURKBPLK4DAPK3JAK2CDK1 | |
| SCHEMBL28557357 | 0.84 | AURKB (0.49) | AURKBALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL28564611 | 0.82 | BPTF (0.42) | ALDH1A1HPGDMAPTBPTFTP53 | |
| SCHEMBL28548957 | 0.81 | ADORA1 (0.44) | AURKBALDH1A1KDM4EMAPTBPTF | |
| SCHEMBL28565368 | 0.81 | AURKB (0.44) | AURKBALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL28022116 | 0.81 | ADORA1 (0.47) | AURKBALDH1A1HPGDKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112755193-A | Method of treating malignancies with anti-tyrosine kinase inhibitors using dianhydrogalactitol or a derivative thereof | 德玛医药 | 2021-05-07 | — | — | CN | disclosed |
| CN-104797267-A | Method of treating tyrosine kinase inhibitor-resistant malignancies in patients with genetic polymorphism or AHI1 dysregulation or mutation using dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof | DEL MAR PHARMACEUTICALS | 2015-07-22 | — | — | CN | disclosed |