SCHEMBL28021844

SCHEMBL28021844

O=C(O)CCC(Cl)(Cl)c1ccccc1.[NaH]

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.47
CYP2C19 P33261 4/20 0.42
HIF1A Q16665 1/20 0.42
KEAP1 Q14145 1/20 0.42
ALDH1A1 P00352 5/20 0.42
ESR1 P03372 1/20 0.42
CYP3A4 P08684 1/20 0.42
ESR2 Q92731 1/20 0.42
NR4A2 P43354 1/20 0.41
HDAC3 O15379 2/20 0.39
HDAC4 P56524 2/20 0.39
HDAC1 Q13547 2/20 0.39
HDAC7 Q8WUI4 2/20 0.39
HDAC2 Q92769 2/20 0.39
HDAC10 Q969S8 2/20 0.39
HDAC11 Q96DB2 2/20 0.39
HDAC8 Q9BY41 2/20 0.39
HDAC6 Q9UBN7 2/20 0.39
HDAC9 Q9UKV0 2/20 0.39
HDAC5 Q9UQL6 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27621428 0.98 CYP1A2 (0.48) CYP1A2CYP2C19HIF1AKEAP1ALDH1A1
SCHEMBL8166179 0.86 CYP1A2 (0.48) CYP1A2CYP2C19HIF1AKEAP1ALDH1A1
SCHEMBL19656194 0.79 CYP1A2 (0.42) CYP1A2CYP2C19HIF1AALDH1A1MAPK1
SCHEMBL8166176 0.77 CYP1A2 (0.44) CYP1A2CYP2C19HIF1AALDH1A1CYP3A4
SCHEMBL4873449 0.77 CYP2C19 (0.47) CYP1A2CYP2C19HIF1AKEAP1ALDH1A1
SCHEMBL5329346 0.77 KIF11 (0.53) CYP1A2CYP2C19HIF1AKEAP1ALDH1A1
SCHEMBL6548609 0.77 HIF1A (0.57) CYP1A2CYP2C19HIF1AKEAP1ALDH1A1
SCHEMBL13851657 0.75 CYP2C19 (0.45) CYP1A2CYP2C19HIF1AKEAP1ALDH1A1
SCHEMBL7531100 0.75 CYP2C19 (0.45) CYP1A2CYP2C19HIF1AKEAP1ALDH1A1
SCHEMBL9098506 0.75 CYP2C19 (0.45) CYP1A2CYP2C19HIF1AKEAP1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104672083-A Cornfield herbicide compound and application thereof SHANDONG CYNDA CHEMICAL CO LTD 2015-06-03 CN disclosed