Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.36 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.36 |
| ▸ | PARP4 | Q9UKK3 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.36 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.36 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28022482 | 0.75 | ERN1 (0.35) | MAPTTDP1SMN1; SMN2ALDH1A1PARP10 | |
| SCHEMBL27885465 | 0.74 | MAOA (0.55) | ALDH1A1SENP8SENP6CYP2C9CYP2C19 | |
| SCHEMBL27525431 | 0.73 | CYP2C9 (0.42) | MAPTTDP1ALDH1A1SENP8SENP6 | |
| SCHEMBL2084173 | 0.70 | MAPT (0.62) | MAPTTDP1SMN1; SMN2ALDH1A1CA2 | |
| SCHEMBL8155209 | 0.69 | MAPT (0.61) | MAPTTDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4153725 | 0.69 | MAPT (0.61) | MAPTTDP1SMN1; SMN2ALDH1A1CYP2C19 | |
| SCHEMBL12470822 | 0.69 | MAPT (0.56) | MAPTTDP1SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL2084131 | 0.69 | MAPT (0.66) | MAPTTDP1SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL3333833 | 0.68 | PARP1 (0.50) | CYP2C9PARP10PARP1L3MBTL1PARP2 | |
| SCHEMBL1758181 | 0.67 | CYP2C9 (0.55) | CYP2C9PARP10PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104854092-A | PYRIDINE-2-AMIDES USEFUL AS CB2 AGONISTS | HOFFMANN LA ROCHE | 2015-08-19 | — | — | CN | claimed |
| CN-104854092-A | PYRIDINE-2-AMIDES USEFUL AS CB2 AGONISTS | HOFFMANN LA ROCHE | 2015-08-19 | — | — | CN | disclosed |