Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4655299 | 0.79 | MAPT (0.66) | MAPTTDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2084173 | 0.77 | MAPT (0.62) | MAPTTDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4153725 | 0.76 | MAPT (0.61) | MAPTTDP1SMN1; SMN2ALDH1A1ERN1 | |
| SCHEMBL2082827 | 0.76 | MAPT (1.00) | MAPTTDP1SMN1; SMN2ALDH1A1ERN1 | |
| Bicarbonate SCHEMBL9826841 | 0.73 | MAPT (0.58) | MAPTTDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8193763 | 0.73 | MAPT (0.41) | MAPTTDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4924273 | 0.72 | ALDH1A1 (1.00) | MAPTTDP1SMN1; SMN2ALDH1A1ERN1 | |
| SCHEMBL2084131 | 0.72 | MAPT (0.66) | MAPTTDP1SMN1; SMN2ALDH1A1ERN1 | |
| SCHEMBL28022020 | 0.69 | MAPT (0.57) | MAPTTDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3213057 | 0.69 | MAOA (0.58) | MAPTTDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1188404-C | Cyclic compound | FUJISAWA PHARMACEUTICAL CO (JP) | 2005-02-09 | — | — | CN | disclosed |
| CN-1425010-A | Cyclic compound | FUJISAWA PHARMACEUTICAL CO (JP) | 2003-06-18 | — | — | CN | disclosed |
| US-6093733-A | FOR THE TREATMENT OR PREVENTION OF DISEASES THE TREATMENT OR PREVENTION OF WHICH IS MEDIATED BY MUSCARINIC RECEPTOR AGONISM; ALZHEIMER'S DISEASE | PFIZER INC. | 2000-07-25 | — | — | US | disclosed |