Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | CTSA | P10619 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | RXRG | P48443 | 1/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 8/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL747071 | 0.84 | CYP11B2 (0.48) | CYP11B2CTSAFFAR1RXRARXRB | |
| SCHEMBL11761023 | 0.81 | SMN1; SMN2 (0.53) | FFAR1RXRARXRBRXRGHDAC3 | |
| SCHEMBL3745313 | 0.81 | CYP11B2 (0.48) | CYP11B2CTSAFFAR1TBXAS1CNR2 | |
| SCHEMBL13048805 | 0.81 | CYP11B2 (0.46) | CYP11B2CTSAFFAR1RXRARXRB | |
| SCHEMBL744436 | 0.79 | CYP11B2 (0.50) | CYP11B2CTSACNR2P2RX7 | |
| SCHEMBL28848215 | 0.77 | CYP11B2 (0.47) | CYP11B2CTSACNR2P2RX7 | |
| SCHEMBL2570576 | 0.74 | TBXAS1 (0.56) | FFAR1TBXAS1HDAC3MAPK1ADRA1A | |
| SCHEMBL750857 | 0.72 | CYP11B2 (0.55) | CYP11B2CTSATBXAS1SMN1; SMN2CNR2 | |
| SCHEMBL11760114 | 0.70 | HDAC3 (0.61) | FFAR1HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL21475996 | 0.69 | FFAR1 (0.64) | FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104892502-B | It is used as the aryl-pyridine of aldosterone synthase inhibitors | 诺华股份有限公司 | 2017-08-04 | — | — | CN | disclosed |
| CN-104892502-A | Aryl pyridine as aldosterone synthase inhibitors | NOVARTIS AG | 2015-09-09 | — | — | CN | disclosed |
| CN-102803217-B | Aryl pyridines as aldosterone synthase inhibitors | NOVARTIS AG | 2015-06-17 | — | — | CN | disclosed |