Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.35 |
| ▸ | CES1 | P23141 | 2/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.32 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | FPR2 | P25090 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
| ▸ | RXRA | P19793 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7596485 | 0.83 | SOS1 (0.36) | CES2CES1GABRG2GABRB3GABRA5 | |
| SCHEMBL28825098 | 0.83 | CES2 (0.55) | CES2CES1GABRG2GABRB3GABRA5 | |
| SCHEMBL11991549 | 0.81 | SOS1 (0.45) | CES2CES1SOS1TDP1 | |
| SCHEMBL22982350 | 0.80 | GABRG2 (0.43) | CES2CES1GABRG2GABRB3GABRA5 | |
| SCHEMBL7593685 | 0.78 | CFTR (0.39) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL22322520 | 0.76 | POLB (0.37) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL20569518 | 0.75 | SOS1 (0.36) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL15075231 | 0.75 | CFTR (0.36) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL30289413 | 0.75 | TTR (0.48) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL27397892 | 0.75 | TTR (0.48) | GABRG2GABRB3GABRA5GABRA1GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104797555-A | N-substituted benzamides and methods of use thereof | GENENTECH INC | 2015-07-22 | — | — | CN | disclosed |