SCHEMBL28024927

SCHEMBL28024927

CCc1ccc(Cc2ccc(O)c(Cl)c2)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.53
HSD17B10 Q99714 2/20 0.53
CYP1A2 P05177 1/20 0.53
CYP2D6 P10635 1/20 0.53
CYP2C9 P11712 1/20 0.53
CYP2C19 P33261 1/20 0.53
HDAC8 Q9BY41 1/20 0.51
CA2 P00918 7/20 0.50
TRPA1 O75762 1/20 0.50
ESR1 P03372 1/20 0.48
ESR2 Q92731 1/20 0.48
CA1 P00915 5/20 0.48
CA4 P22748 1/20 0.48
CA6 P23280 1/20 0.48
IDH1 O75874 1/20 0.46
TSHR P16473 1/20 0.43
HSP90AA1 P07900 1/20 0.41
HSP90AB1 P08238 1/20 0.41
IGF1R P08069 1/20 0.41
ALOX15 P16050 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL157976 0.88 TRPA1 (0.64) CYP3A4HSD17B10CYP1A2CYP2D6CYP2C9
SCHEMBL30582486 0.88 TRPA1 (0.64) CYP3A4HSD17B10CYP1A2CYP2D6CYP2C9
SCHEMBL71042 0.88 HSD17B10 (0.63) CYP3A4HSD17B10CYP1A2CYP2D6CYP2C9
SCHEMBL27704410 0.85 ESR1 (0.53) CYP3A4HSD17B10CYP1A2CYP2D6CYP2C9
SCHEMBL744471 0.82 IDH1 (0.68) CYP3A4HSD17B10CYP1A2CYP2D6CYP2C9
SCHEMBL6249245 0.77 CYP3A4 (0.57) CYP3A4HSD17B10CYP1A2CYP2D6CYP2C9
SCHEMBL11143328 0.77 CYP3A4 (0.53) CYP3A4HSD17B10CYP1A2CYP2D6CYP2C9
SCHEMBL10827100 0.77 CYP3A4 (0.45) CYP3A4HSD17B10CYP1A2CYP2D6CYP2C9
SCHEMBL10826441 0.77 ALOX5 (0.47) CYP3A4HSD17B10CYP1A2CYP2D6CYP2C9
SCHEMBL631374 0.76 CNR1 (0.64) CYP3A4HSD17B10CYP1A2CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104803957-A Benzylic glycoside derivatives and methods of use THERACOS INC 2015-07-29 CN disclosed