Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 19/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 11/20 | 0.58 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2802051 | 0.93 | TGFBR1 (0.60) | TGFBR1MAPK14CHRM5 | |
| SCHEMBL2799154 | 0.88 | TGFBR1 (0.47) | TGFBR1MAPK14 | |
| SCHEMBL13232315 | 0.87 | TGFBR1 (0.47) | TGFBR1MAPK14 | |
| SCHEMBL2795968 | 0.83 | TGFBR1 (0.45) | TGFBR1MAPK14TGFBR2 | |
| SCHEMBL8229819 | 0.83 | TGFBR1 (0.43) | TGFBR1MAPK14 | |
| SCHEMBL2801317 | 0.82 | TGFBR1 (0.45) | TGFBR1MAPK14 | |
| SCHEMBL2800414 | 0.81 | TGFBR1 (0.44) | TGFBR1MAPK14 | |
| SCHEMBL8235620 | 0.79 | TGFBR1 (0.49) | TGFBR1MAPK14 | |
| SCHEMBL8236356 | 0.72 | TGFBR1 (0.51) | TGFBR1MAPK14 | |
| SCHEMBL8236655 | 0.71 | TGFBR1 (0.50) | TGFBR1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100166819-A1 | Transforming Growth Factor Modulators | BIOGEN IDEC MA INC. A CORPORATION | 2010-07-01 | — | — | US | disclosed |
| US-20100166819-A1 | Transforming Growth Factor Modulators | BIOGEN IDEC MA INC. A CORPORATION | 2010-07-01 | — | — | US | disclosed |
| US-20100166819-A1 | Transforming Growth Factor Modulators | BIOGEN IDEC MA INC. A CORPORATION | 2010-07-01 | — | — | US | disclosed |
| WO-2007076086-A2 | TRICYCLIC SPIRO COMPOUNDS USEFUL AS TRANSFORMING GROWTH FACTOR MODULATORS | BIOGEN IDEC MA INC (US) | 2007-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100166819-A1 | Transforming Growth Factor Modulators | ACVR1, TGFBR1, ACVRL1 | TGFBR1 2/4885MAPK14 927/4885TGFBR2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.