Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 7/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | DDX3X | O00571 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2453168 | 0.84 | TP53 (0.49) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL2453170 | 0.84 | TP53 (0.49) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL1815772 | 0.80 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL2311749 | 0.80 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL2312487 | 0.80 | MEN1 (0.48) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL4014610 | 0.78 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL1028316 | 0.77 | OPRM1 (0.43) | ALDH1A1MEN1KMT2AMAPTPOLB | |
| SCHEMBL1027116 | 0.76 | MAOB (0.47) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL1027117 | 0.76 | MAOB (0.47) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL18053692 | 0.76 | ALDH1A1 (0.40) | ALDH1A1MEN1KMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104755461-A | 6-aminoindole derivatives as TRP channel antagonists | HOFFMANN LA ROCHE | 2015-07-01 | — | — | CN | disclosed |