SCHEMBL28026041

SCHEMBL28026041

c1cnc2cc(-c3ccon3)ccc2c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 4/20 0.49
RAB9A P51151 3/20 0.49
ALDH1A1 P00352 3/20 0.46
CYP1A2 P05177 2/20 0.46
CYP2C19 P33261 2/20 0.46
MEN1 O00255 1/20 0.46
CASP1 P29466 1/20 0.46
CASP7 P55210 1/20 0.46
KMT2A Q03164 1/20 0.46
HTT P42858 1/20 0.46
NR4A2 P43354 1/20 0.46
POLB P06746 1/20 0.44
GSK3B P49841 1/20 0.43
TRPV1 Q8NER1 3/20 0.39
CYP2D6 P10635 1/20 0.39
CYP19A1 P11511 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP3A4 P08684 1/20 0.38
HDAC3 O15379 1/20 0.37
HDAC4 P56524 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3726615 0.78 NPC1 (0.68) NPC1RAB9AALDH1A1CYP1A2CYP2C19
SCHEMBL29485612 0.78 NPC1 (0.68) NPC1RAB9AALDH1A1CYP1A2CYP2C19
SCHEMBL27569703 0.78 NPC1 (0.65) NPC1RAB9AALDH1A1CYP1A2CYP2C19
SCHEMBL29696597 0.78 NPC1 (0.65) NPC1RAB9AALDH1A1CYP1A2CYP2C19
SCHEMBL9838799 0.76 ALDH1A1 (0.52) NPC1RAB9AALDH1A1CYP1A2CYP2C19
SCHEMBL31121089 0.76 ALDH1A1 (0.52) NPC1RAB9AALDH1A1CYP1A2CYP2C19
SCHEMBL7914859 0.75 NPC1 (0.58) NPC1RAB9AALDH1A1CYP1A2CYP2C19
SCHEMBL30938000 0.75 NPC1 (0.58) NPC1RAB9AALDH1A1CYP1A2CYP2C19
SCHEMBL6034300 0.74 ALDH1A1 (0.46) NPC1RAB9AALDH1A1CYP1A2CYP2C19
SCHEMBL6034085 0.74 NR4A2 (0.54) NPC1RAB9AALDH1A1CYP1A2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104755473-B 2,3 benzodiazepine * 拜耳医药股份有限公司 2017-03-08 CN disclosed
CN-105492436-A Substituted phenyl-2,3-benzodiazepines Bayer Pharma AG 2016-04-13 CN disclosed
CN-104755473-A 2,3-benzodiazepines Bayer Pharma AG 2015-07-01 CN disclosed