Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.32 |
| ▸ | CA2 | P00918 | 3/20 | 0.32 |
| ▸ | CA7 | P43166 | 3/20 | 0.32 |
| ▸ | CA9 | Q16790 | 3/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | KDM1A | O60341 | 4/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.30 |
| ▸ | PPARA | Q07869 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28809901 | 0.80 | CHRNB2 (0.41) | CA1CA2CA7CA9CA14 | |
| SCHEMBL27901789 | 0.74 | KDM1A (0.47) | KDM1AADRB2 | |
| SCHEMBL1726570 | 0.72 | PARP10 (0.48) | — | |
| SCHEMBL13186621 | 0.70 | PARP10 (0.32) | CYP3A4SMN1; SMN2 | |
| SCHEMBL27818616 | 0.70 | CA1 (0.50) | CA1CA2CA7CA9CA14 | |
| SCHEMBL28770047 | 0.70 | ADRA2A (0.41) | CA1CA2CA7CA9CA14 | |
| SCHEMBL17732769 | 0.70 | KDM1A (0.43) | CA1CA2CA7CA9CA14 | |
| SCHEMBL27975898 | 0.70 | KDM1A (0.43) | CA1CA2CA7CA9CA14 | |
| SCHEMBL27913921 | 0.68 | CA1 (0.46) | CA1CA2CA7CA9CA14 | |
| SCHEMBL27343433 | 0.67 | HTR2C (0.49) | KDM1AADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105001206-A | Inhibitors of Bruton's Tyrosine Kinase | HOFFMANN LA ROCHE | 2015-10-28 | — | — | CN | disclosed |
| CN-102341383-B | Inhibitors of bruton's tyrosine kinase | HOFFMAN-LA ROCHE LTD. (CH) | 2015-09-16 | — | — | CN | disclosed |