Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.32 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL279604 | 0.85 | ALDH1A1 (0.33) | — | |
| SCHEMBL280344 | 0.84 | — | — | |
| SCHEMBL280241 | 0.81 | MKNK1 (0.31) | BAZ2A | |
| SCHEMBL259324 | 0.80 | BAZ2A (0.35) | BAZ2ACHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL280275 | 0.75 | MAPT (0.33) | — | |
| SCHEMBL280449 | 0.71 | — | — | |
| SCHEMBL279873 | 0.69 | ALDH1A1 (0.39) | — | |
| SCHEMBL13763088 | 0.69 | CYP1A2 (0.34) | — | |
| SCHEMBL280473 | 0.69 | RAB9A (0.39) | CDK2 | |
| SCHEMBL4419714 | 0.69 | TSHR (0.41) | BAZ2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8134010-B2 | 4-[4-Methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-phenylamine; N-{4-[4-Methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-phenyl}-acetamide; or4-Methyl-5-(2-nitrooxy-ethyl)-2-(4-nitro-phenyl)-thiazole; cardiovascular, gastrointestinal, inflammatory, respiratory disease | RENOPHARM LTD. (IL) | 2012-03-13 | — | — | US | disclosed |