Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | ELANE | P08246 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29034256 | 0.98 | KMT2A (0.56) | POLBKMT2AHTTSMN1; SMN2TDP1 | |
| SCHEMBL21494386 | 0.95 | KMT2A (0.61) | POLBKMT2AHTTSMN1; SMN2TDP1 | |
| SCHEMBL27999904 | 0.92 | ALDH1A1 (0.51) | POLBKMT2AHTTSMN1; SMN2TDP1 | |
| Hydrochloric Acid SCHEMBL28617927 | 0.90 | KMT2A (0.51) | POLBKMT2AHTTSMN1; SMN2TDP1 | |
| Hydrochloric Acid SCHEMBL27439494 | 0.84 | CHRNB2 (0.50) | POLBKMT2AHTTSMN1; SMN2TDP1 | |
| SCHEMBL10782887 | 0.80 | POLB (0.76) | POLBKMT2AHTTSMN1; SMN2TDP1 | |
| SCHEMBL10911289 | 0.80 | POLB (0.76) | POLBKMT2AHTTSMN1; SMN2TDP1 | |
| SCHEMBL234456 | 0.80 | POLB (0.76) | POLBKMT2AHTTSMN1; SMN2TDP1 | |
| SCHEMBL10949493 | 0.80 | POLB (0.76) | POLBKMT2AHTTSMN1; SMN2TDP1 | |
| SCHEMBL10955716 | 0.80 | POLB (0.76) | POLBKMT2AHTTSMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102858778-B | Heterobiaryl-cyclohexyl-tetrazine is [e] Azulene also | HOFFMAN-LA ROCHE LTD. (CH) | 2015-08-26 | — | — | CN | disclosed |