Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 2/20 | 0.71 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.71 |
| ▸ | PTGS1 | P23219 | 11/20 | 0.67 |
| ▸ | POLA1 | P09884 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14610133 | 1.00 | NR1H3 (0.71) | NR1H3PTPN1PTGS1POLA1 | |
| SCHEMBL280365 | 0.90 | NR1H3 (0.58) | NR1H3PTPN1PTGS1 | |
| SCHEMBL823257 | 0.88 | PTGS1 (0.57) | NR1H3PTPN1PTGS1 | |
| SCHEMBL280024 | 0.87 | NR1H3 (0.55) | NR1H3PTPN1PTGS1 | |
| SCHEMBL12704605 | 0.87 | PTGS1 (0.55) | NR1H3PTPN1PTGS1POLA1 | |
| SCHEMBL280111 | 0.87 | PTGS1 (0.55) | NR1H3PTPN1PTGS1POLA1 | |
| SCHEMBL280037 | 0.86 | NR1H3 (0.54) | NR1H3PTPN1PTGS1 | |
| SCHEMBL280021 | 0.86 | NR1H3 (0.62) | NR1H3PTPN1PTGS1 | |
| SCHEMBL280502 | 0.86 | NR1H3 (0.56) | NR1H3PTPN1PTGS1 | |
| SCHEMBL823259 | 0.85 | PTGS1 (0.56) | NR1H3PTPN1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912932-B1 | INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-A MODULATORS; SYNTHESES OF SUCH MODULATORS AND METHODS OF USING SUCH MODULATORS | NEREUS PHARMACEUTICALS INC (US) | 2012-05-02 | — | — | EP | disclosed |
| US-8133915-B2 | Interleukin-1 and tumor necrosis factor-α modulators; syntheses of such modulators and methods of using such modulators | NEREUS PHARMACEUTICALS, INC. (US) | 2012-03-13 | — | — | US | disclosed |
| US-20110160309-A1 | INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-ALPHA MODULATORS; SYNTHESES OF SUCH MODULATORS AND METHODS OF USING SUCH MODULATORS | NEREUS PHARMACEUTICALS, INC. (US) | 2011-06-30 | — | — | US | disclosed |
| EP-2311795-A2 | Interleukin-1 and tumor necrosis factor-alpha modulators; syntheses of such modulators and methods of using such modulators | Nereus Pharmaceuticals, Inc. (US) | 2011-04-20 | — | — | EP | disclosed |
| US-7893299-B2 | Acanthoic amide derivatives; inflammation, cancer, cachexia, cardiovascular disease, infections, diabetes, otitis media, sinusitis, transplant rejection | NEREUS PHARMACEUTICALS, INC. (US) | 2011-02-22 | — | — | US | disclosed |
| US-20080188475-A1 | Novel Interleukin-1 and Tumor Necrosis Factor-Alpha Modulators, Syntheses of Said Modulators and Their Enantiomers and Methods of Using Said Modulators | NEREUS PHAMACEUTICALS, INC. (US) | 2008-08-07 | — | — | US | disclosed |
| US-20080064753-A1 | Interleukin-1 and tumor necrosis factor-alpha modulators; syntheses of such modulators and methods of using such modulators | HENSLER, MARY | 2008-03-13 | — | — | US | disclosed |
| US-7342125-B2 | Method of treating inflammation with acanthoic acid derivatives | NEREUS PHARMACEUTICALS, INC. (US) | 2008-03-11 | — | — | US | disclosed |
| EP-1178952-B1 | NOVEL INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-ALPHA MODULATORS, SYNTHESES OF SAID MODULATORS AND METHODS OF USING SAID MODULATORS | NEREUS PHARMACEUTICALS INC (US) | 2007-08-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080188475-A1 | Novel Interleukin-1 and Tumor Necrosis Factor-Alpha Modulators, Syntheses of Said Modulators and Their Enantiomers and Methods of Using Said Modulators | IL1A, IL1B, TNF | NR1H3 1132/4885PTPN1 2311/4885PTGS1 11/4885 |
| US-20110160309-A1 | INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-ALPHA MODULATORS; SYNTHESES OF SUCH MODULATORS AND METHODS OF USING SUCH MODULATORS | IL1A, IL1B, TNF | NR1H3 3538/4885PTPN1 2008/4885PTGS1 20/4885 |
| US-20080064753-A1 | Interleukin-1 and tumor necrosis factor-alpha modulators; syntheses of such modulators and methods of using such modulators | IL1A, IL1B, TNF | NR1H3 3538/4885PTPN1 2008/4885PTGS1 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.