Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 1.00 |
| ▸ | ARG2 | P78540 | 4/20 | 0.59 |
| ▸ | ARG1 | P05089 | 3/20 | 0.59 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.52 |
| ▸ | GRM8 | O00222 | 1/20 | 0.52 |
| ▸ | GRM6 | O15303 | 1/20 | 0.52 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.52 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.52 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.52 |
| ▸ | GRM5 | P41594 | 1/20 | 0.52 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.52 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.52 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.52 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.52 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.52 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.52 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.52 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL8613373 | 1.00 | GSR (1.00) | GSRARG2ARG1RNPEPCYP1A2 | |
| Lysine SCHEMBL456381 | 1.00 | GSR (1.00) | GSRARG2ARG1RNPEPCYP1A2 | |
| Lysine SCHEMBL3359527 | 1.00 | GSR (1.00) | GSRARG2ARG1RNPEPCYP1A2 | |
| Lysine SCHEMBL1645 | 1.00 | GSR (1.00) | GSRARG2ARG1RNPEPCYP1A2 | |
| Lysine SCHEMBL12867528 | 1.00 | GSR (1.00) | GSRARG2ARG1RNPEPCYP1A2 | |
| Lysine SCHEMBL1000151 | 1.00 | GSR (1.00) | GSRARG2ARG1RNPEPCYP1A2 | |
| Lysine SCHEMBL9439278 | 1.00 | GSR (1.00) | GSRARG2ARG1RNPEPCYP1A2 | |
| Lysine SCHEMBL20362357 | 1.00 | GSR (1.00) | GSRARG2ARG1RNPEPCYP1A2 | |
| Lysine SCHEMBL7343 | 1.00 | GSR (1.00) | GSRARG2ARG1RNPEPCYP1A2 | |
| Lysine SCHEMBL15303774 | 1.00 | GSR (1.00) | GSRARG2ARG1RNPEPCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210347866-A1 | PEPTIDE IMMUNOGEN CONSTRUCTS DIRECTED AGAINST DIPEPTIDE REPEAT PROTEINS FROM C9ORF72 | UNITED NEUROSCIENCE (KY) | 2021-11-11 | — | — | US | disclosed |
| EP-3861007-A1 | PEPTIDE IMMUNOGEN CONSTRUCTS DIRECTED AGAINST DIPEPTIDE REPEAT PROTEINS FROM C9ORF72 | United Neuroscience (KY) | 2021-08-11 | — | — | EP | disclosed |
| WO-2020072428-A1 | PEPTIDE IMMUNOGEN CONSTRUCTS DIRECTED AGAINST DIPEPTIDE REPEAT PROTEINS FROM C9ORF72 | UNITED NEUROSCIENCE (KY) | 2020-04-09 | — | — | WO | disclosed |
| EP-3302577-A1 | OPTIMISED MULTIVALENT TARGETING FLUORESCENT TRACER | Fluoptics (FR) | 2018-04-11 | — | — | EP | disclosed |
| EP-3237360-A1 | COMPOSITIONS WITH IMPROVED UREASE-INHIBITING EFFECT COMPRISING (THIO) PHOSPHORIC ACID TRIAMIDE AND FURTHER COMPOUNDS SUCH AS AMINES AND COLORANTS | BASF SE (DE) | 2017-11-01 | — | — | EP | disclosed |
| CN-103648527-B | Synthetic peptide-based marker vaccine and diagnostic system for effective control of porcine reproductive and respiratory syndrome (PRRS) | 美国联合生物医学公司 | 2017-03-22 | — | — | CN | disclosed |
| WO-2016103168-A1 | COMPOSITIONS WITH IMPROVED UREASE-INHIBITING EFFECT COMPRISING (THIO) PHOSPHORIC ACID TRIAMIDE AND FURTHER COMPOUNDS SUCH AS AMINES AND COLORANTS | BASF SE (DE) | 2016-06-30 | — | — | WO | disclosed |
| EP-2197295-A1 | HETEROMORPHIC LYSINE FEED GRANULES | Archer-Daniels-Midland Company (US) | 2010-06-23 | — | — | EP | disclosed |
| WO-2009042779-A1 | HETEROMORPHIC LYSINE FEED GRANULES | ARCHER-DANIELS-MIDLAND COMPANY (US) | 2009-04-02 | — | — | WO | disclosed |