SCHEMBL28027939

SCHEMBL28027939

O=C(C(=O)c1nccs1)c1nccs1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.67
PLA2G4A P47712 1/20 0.43
CES1 P23141 1/20 0.42
TSHR P16473 1/20 0.42
NOS1 P29475 1/20 0.42
HSD17B10 Q99714 1/20 0.42
RBBP9 O75884 5/20 0.41
CASP3 P42574 3/20 0.40
SENP8 Q96LD8 3/20 0.40
SENP7 Q9BQF6 3/20 0.40
SENP6 Q9GZR1 3/20 0.40
PLA2G7 Q13093 1/20 0.40
HSPA9 P38646 1/20 0.40
CYP1A2 P05177 2/20 0.39
CYP2D6 P10635 2/20 0.39
CYP2C19 P33261 2/20 0.39
ADORA2A P29274 1/20 0.39
ADORA1 P30542 1/20 0.39
MAPT P10636 1/20 0.39
FBP1 P09467 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11254334 0.88 ALDH1A1 (0.59) ALDH1A1PLA2G4ACES1TSHRNOS1
SCHEMBL5609781 0.86 ALDH1A1 (0.57) ALDH1A1PLA2G4ACES1TSHRNOS1
SCHEMBL5609136 0.86 ALDH1A1 (0.69) ALDH1A1PLA2G4ACES1TSHRNOS1
SCHEMBL175249 0.84 ALDH1A1 (0.67) ALDH1A1PLA2G4ACES1TSHRNOS1
SCHEMBL12801063 0.83 ALDH1A1 (0.64) ALDH1A1PLA2G4ACES1RBBP9CASP3
Hydrochloric Acid SCHEMBL27980177 0.82 ALDH1A1 (0.64) ALDH1A1PLA2G4ACES1TSHRNOS1
SCHEMBL121301 0.82
SCHEMBL2170448 0.82
SCHEMBL10831806 0.81 ALDH1A1 (0.52) ALDH1A1PLA2G4ACES1TSHRNOS1
SCHEMBL8973785 0.81 ALDH1A1 (0.52) ALDH1A1PLA2G4ACES1TSHRNOS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104870429-A Benzofuran derivative, preparation method therefor, and medical application thereof SICHUAN HAISCO PHARMACEUTICAL CO LTD 2015-08-26 CN claimed
CN-104870429-A Benzofuran derivative, preparation method therefor, and medical application thereof SICHUAN HAISCO PHARMACEUTICAL CO LTD 2015-08-26 CN disclosed