SCHEMBL28028231

SCHEMBL28028231

FC(F)(F)C(F)(c1ccccc1I)C(F)(F)F

nearest known ligand 0.32

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 1/20 0.31
ALDH1A1 P00352 2/20 0.31
POLB P06746 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
TSHR P16473 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6862432 0.81
SCHEMBL3672313 0.80 ALDH1A1 (0.31) ALDH1A1POLBTDP1L3MBTL1TSHR
SCHEMBL3677273 0.79 ALDH1A1 (0.33) ALDH1A1POLBTDP1L3MBTL1TSHR
SCHEMBL11526 0.79 ALDH1A1 (0.43) KIF11ALDH1A1POLBTDP1L3MBTL1
SCHEMBL29673099 0.79 ALDH1A1 (0.43) KIF11ALDH1A1POLBTDP1L3MBTL1
SCHEMBL6862711 0.78
SCHEMBL6862991 0.78
SCHEMBL3676036 0.76
SCHEMBL19746100 0.76 MEN1 (0.44) ALDH1A1POLBTSHR
SCHEMBL3674084 0.75

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104829420-B A kind of method that directly aryl diazonium salts is carried out seven fluorine isopropylations by hexafluoropropene 中国科学院上海有机化学研究所 2016-09-14 CN disclosed
CN-104829420-A Method for carrying out direct heptafluoro-isopropylation on aryl diazo salts through hexafluoropropylene SHANGHAI INST ORGANIC CHEM 2015-08-12 CN disclosed