Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfamethazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.94 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.94 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.94 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.94 |
| ▸ | GAA | P10253 | 4/20 | 0.68 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | PDE4A | P27815 | 1/20 | 0.62 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfamethazine SCHEMBL151305 | 0.97 | ALDH1A1 (1.00) | ALDH1A1CYP3A4SMN1; SMN2TDP1GAA | |
| Sulfamethazine SCHEMBL17256221 | 0.97 | ALDH1A1 (1.00) | ALDH1A1CYP3A4SMN1; SMN2TDP1GAA | |
| Sulfamethazine SCHEMBL29918086 | 0.97 | ALDH1A1 (1.00) | ALDH1A1CYP3A4SMN1; SMN2TDP1GAA | |
| Sulfamethazine SCHEMBL11708760 | 0.95 | ALDH1A1 (0.91) | ALDH1A1CYP3A4SMN1; SMN2TDP1GAA | |
| Sulfamethazine SCHEMBL1442165 | 0.95 | ALDH1A1 (0.97) | ALDH1A1CYP3A4SMN1; SMN2TDP1GAA | |
| Sulfamethazine SCHEMBL3495558 | 0.95 | ALDH1A1 (0.97) | ALDH1A1CYP3A4SMN1; SMN2TDP1GAA | |
| Sulfamethazine SCHEMBL28567572 | 0.95 | ALDH1A1 (0.97) | ALDH1A1CYP3A4SMN1; SMN2TDP1GAA | |
| Sulfamethazine SCHEMBL29243922 | 0.94 | ALDH1A1 (0.88) | ALDH1A1CYP3A4SMN1; SMN2TDP1GAA | |
| Sulfamethazine SCHEMBL28447030 | 0.93 | ALDH1A1 (0.86) | ALDH1A1CYP3A4SMN1; SMN2TDP1GAA | |
| Sulfamethazine SCHEMBL2428342 | 0.91 | ALDH1A1 (0.88) | ALDH1A1CYP3A4SMN1; SMN2TDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105203623-B | The dizzy application as MALDI-TOF MS substrate in little Molecular Detection of six tert-butyl groups-six hexyloxy-six benzo [ab, de, lm, op, rs, uv] | 陕西师范大学 | 2016-07-27 | — | — | CN | disclosed |
| CN-105203623-A | Application of 6-tertiary butyl-6-hexyloxy-6-benzo[a,b,de,lm,op,rs,uv]coronene as MALDI-TOF MS matrix in micromolecule detection | UNIV SHAANXI NORMAL | 2015-12-30 | — | — | CN | disclosed |