Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfamethazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.97 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.97 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.97 |
| ▸ | GAA | P10253 | 4/20 | 0.69 |
| ▸ | TSHR | P16473 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.68 |
| ▸ | PDE4A | P27815 | 1/20 | 0.64 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.63 |
| ▸ | PKM | P14618 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.57 |
| ▸ | DHFR | P00374 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfamethazine SCHEMBL29918086 | 0.98 | ALDH1A1 (1.00) | ALDH1A1CYP3A4SMN1; SMN2TDP1GAA | |
| Sulfamethazine SCHEMBL151305 | 0.98 | ALDH1A1 (1.00) | ALDH1A1CYP3A4SMN1; SMN2TDP1GAA | |
| Sulfamethazine SCHEMBL17256221 | 0.98 | ALDH1A1 (1.00) | ALDH1A1CYP3A4SMN1; SMN2TDP1GAA | |
| Sulfamethazine SCHEMBL1442165 | 0.97 | ALDH1A1 (0.97) | ALDH1A1CYP3A4SMN1; SMN2TDP1GAA | |
| Sulfamethazine SCHEMBL28567572 | 0.97 | ALDH1A1 (0.97) | ALDH1A1CYP3A4SMN1; SMN2TDP1GAA | |
| Sulfamethazine SCHEMBL28028309 | 0.95 | ALDH1A1 (0.94) | ALDH1A1CYP3A4SMN1; SMN2TDP1GAA | |
| Sulfamethazine SCHEMBL11708760 | 0.94 | ALDH1A1 (0.91) | ALDH1A1CYP3A4SMN1; SMN2TDP1GAA | |
| Sulfamethazine SCHEMBL29243922 | 0.92 | ALDH1A1 (0.88) | ALDH1A1CYP3A4SMN1; SMN2TDP1GAA | |
| Sulfamethazine SCHEMBL2428342 | 0.92 | ALDH1A1 (0.88) | ALDH1A1CYP3A4SMN1; SMN2TDP1GAA | |
| Sulfamethazine SCHEMBL28447030 | 0.91 | ALDH1A1 (0.86) | ALDH1A1CYP3A4SMN1; SMN2TDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1194777-C | Artificial skin and its prepn and use | SHANDONG LUYE PHARM CO LTD (CN) | 2005-03-30 | — | — | CN | claimed |
| CN-1347736-A | Artificial skin and its prepn and use | SHANDONG LUYE PHARM CO LTD (CN) | 2002-05-08 | — | — | CN | claimed |
| US-11254735-B2 | Prevention of tissue ischemia and related methods | The United States of America, as represented by the Secretary, Depar tment of Health and Human Services (US) | 2022-02-22 | — | — | US | disclosed |
| US-20210355495-A1 | METHODS TO ELIMINATE CANCER STEM CELLS BY TARGETING CD47 | THE U.S.A, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2021-11-18 | — | — | US | disclosed |
| US-11053314-B2 | Methods to eliminate cancer stem cells by targeting CD47 | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2021-07-06 | — | — | US | disclosed |
| EP-3204420-B1 | METHODS TO ELIMINATE CANCER STEM CELLS BY TARGETING CD47 | US HEALTH (US) | 2020-09-02 | — | — | EP | disclosed |
| US-20200095306-A1 | PREVENTION OF TISSUE ISCHEMIA AND RELATED METHODS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) | 2020-03-26 | — | — | US | disclosed |
| US-10370439-B2 | Prevention of tissue ischemia and related methods | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2019-08-06 | — | — | US | disclosed |
| EP-3424950-A1 | PREVENTION OF TISSUE ISCHEMIA, RELATED METHODS AND COMPOSITIONS | The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services (US) | 2019-01-09 | — | — | EP | disclosed |
| US-20180355032-A1 | METHODS TO ELIMINATE CANCER STEM CELLS BY TARGETING CD47 | THE U.S.A, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2018-12-13 | — | — | US | disclosed |
| EP-2695896-B1 | Prevention of tissue ischemia, related methods and compositions | US GOV HEALTH & HUMAN SERVICES (US) | 2018-08-22 | — | — | EP | disclosed |
| WO-2008060785-A2 | PREVENTION OF TISSUE ISCHEMIA, RELATED METHODS AND COMPOSITIONS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2008-05-22 | — | — | WO | disclosed |
| US-7129021-B2 | Polymer system with switchable physical properties and its use in direct exposure printing plates | CREO SRL (BB) | 2006-10-31 | — | — | US | disclosed |
| EP-1108534-B1 | Polymer system and its use in direct exposure printing plates | CREO S R L (IN) | 2005-08-24 | — | — | EP | disclosed |
| CN-1194777-C | Artificial skin and its prepn and use | SHANDONG LUYE PHARM CO LTD (CN) | 2005-03-30 | — | — | CN | disclosed |
| US-20040081911-A1 | Polymer system with switchable physical properties and its use in direct exposure printing plates | CREO SRL (CA) | 2004-04-29 | — | — | US | disclosed |
| US-20030162129-A1 | Polymer system with switchable physical properties and its use in direct exposure printing plates | CREO SRL | 2003-08-28 | — | — | US | disclosed |
| US-6503691-B1 | Crosslinkable polymer and metal salt of sulfamide derivatives | CREO SRL (BB) | 2003-01-07 | — | — | US | disclosed |
| CN-1347736-A | Artificial skin and its prepn and use | SHANDONG LUYE PHARM CO LTD (CN) | 2002-05-08 | — | — | CN | disclosed |
| EP-1108534-A1 | Polymer system and its use in direct exposure printing plates | Creo S.r.l. (IN) | 2001-06-20 | — | — | EP | disclosed |