Sugi Predict

Sugi Predict / Compounds / SCHEMBL2802838

SCHEMBL2802838

SCHEMBL2802838

O/N=C1\CCCc2ccc(O)cc21

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 2/20 0.55
▸ L3MBTL1 Q9Y468 1/20 0.55
▸ PBRM1 Q86U86 1/20 0.47
▸ MAOB P27338 2/20 0.44
▸ MAOA P21397 1/20 0.44
▸ PRKCI P41743 1/20 0.44
▸ USP2 O75604 1/20 0.41
▸ TSHR P16473 1/20 0.40
▸ HTT P42858 1/20 0.40
▸ POLB P06746 1/20 0.38
▸ CDK5 Q00535 1/20 0.38
▸ CDK5R1 Q15078 1/20 0.38
▸ HSD17B1 P14061 1/20 0.37
▸ LMNA P02545 1/20 0.36
▸ HSD17B10 Q99714 1/20 0.36
▸ DRD2 P14416 1/20 0.35
▸ DRD1 P21728 1/20 0.35
▸ DRD4 P21917 1/20 0.35
▸ DRD5 P21918 1/20 0.35
▸ DRD3 P35462 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2802841 1.00 HPGD (0.55) HPGDL3MBTL1PBRM1MAOBMAOA
SCHEMBL8274688 0.85 MAOA (0.58) HPGDL3MBTL1MAOBMAOAPRKCI
SCHEMBL23950429 0.84 L3MBTL1 (0.53) HPGDL3MBTL1USP2TSHRHTT
SCHEMBL17312874 0.84 L3MBTL1 (0.53) HPGDL3MBTL1USP2TSHRHTT
SCHEMBL29712462 0.84 L3MBTL1 (0.53) HPGDL3MBTL1USP2TSHRHTT
SCHEMBL15956234 0.84 L3MBTL1 (0.53) HPGDL3MBTL1USP2TSHRHTT
SCHEMBL30852970 0.84 L3MBTL1 (0.53) HPGDL3MBTL1USP2TSHRHTT
SCHEMBL5469183 0.80 L3MBTL1 (0.53) HPGDL3MBTL1USP2TSHRHTT
SCHEMBL14409505 0.80 HPGD (0.53) HPGDL3MBTL1USP2TSHRHTT
SCHEMBL5272128 0.80 L3MBTL1 (0.53) HPGDL3MBTL1USP2TSHRHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130296327-A1 SUBSTITUTED HETEROCYLIC COMPOUNDS INCYTE CORPORATION 2013-11-07 — — US disclosed
US-20130296327-A1 SUBSTITUTED HETEROCYLIC COMPOUNDS INCYTE CORPORATION 2013-11-07 — — US disclosed
US-20130296327-A1 SUBSTITUTED HETEROCYLIC COMPOUNDS INCYTE CORPORATION 2013-11-07 — — US disclosed
US-8481732-B2 Substituted heterocyclic compounds INCYTE CORPORATION (US) 2013-07-09 — — US disclosed
US-8481732-B2 Substituted heterocyclic compounds INCYTE CORPORATION (US) 2013-07-09 — — US disclosed
US-8481732-B2 Substituted heterocyclic compounds INCYTE CORPORATION (US) 2013-07-09 — — US disclosed
US-20100240671-A1 SUBSTITUTED HETEROCYCLIC COMPOUNDS INCYTE CORPORATION (US) 2010-09-23 — — US disclosed
US-20100240671-A1 SUBSTITUTED HETEROCYCLIC COMPOUNDS INCYTE CORPORATION (US) 2010-09-23 — — US disclosed
US-20100240671-A1 SUBSTITUTED HETEROCYCLIC COMPOUNDS INCYTE CORPORATION (US) 2010-09-23 — — US disclosed
WO-2010108059-A1 SUBSTITUTED PYRIMIDINE DERIVATIVES AS ANTAGONISTS OF THE HISTAMINE H4 RECEPTOR INCYTE CORPORATION (US) 2010-09-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130296327-A1 SUBSTITUTED HETEROCYLIC COMPOUNDS HRH4, HRH2, HRH1 HPGD 67/4885L3MBTL1 4740/4885PBRM1 978/4885
US-20100240671-A1 SUBSTITUTED HETEROCYCLIC COMPOUNDS HRH4, HRH2, HRH1 HPGD 169/4885L3MBTL1 4861/4885PBRM1 2175/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.