SCHEMBL28028619

SCHEMBL28028619

CC(Br)c1nc2cc(F)ccc2s1

nearest known ligand 0.47

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
DYRK1A Q13627 1/20 0.47
ILK Q13418 1/20 0.45
AHR P35869 1/20 0.43
F2RL3 Q96RI0 3/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4788348 0.86 DYRK1A (0.49) DYRK1AILKAHRF2RL3
SCHEMBL17947421 0.83 DYRK1A (0.50) DYRK1AILKAHR
SCHEMBL20559352 0.83 DYRK1A (0.47) DYRK1AILKAHRF2RL3
SCHEMBL203684 0.80 SMN1; SMN2 (0.53)
SCHEMBL27678865 0.75 LOXL2 (0.62)
SCHEMBL2432396 0.74 F2RL3 (0.51) DYRK1AILKAHRF2RL3
SCHEMBL9335088 0.73 HSD17B10 (0.43) DYRK1A
SCHEMBL30421999 0.73 SMN1; SMN2 (0.57) DYRK1AILKAHR
SCHEMBL1319670 0.73 SMN1; SMN2 (0.57) DYRK1AILKAHR
SCHEMBL2609443 0.72 GFER (0.56) DYRK1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106536518-B Anthelmintic compounds 勃林格殷格翰动物保健美国公司 2020-05-12 CN disclosed
CN-106536518-A Anthelmintic compounds 梅里亚股份有限公司 2017-03-22 CN disclosed
CN-104884453-A Anthelmintic compounds and compositions and methods of using the same MERIAL LTD 2015-09-02 CN disclosed