Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 9/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28198845 | 0.87 | PIK3CD (0.45) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL28028886 | 0.87 | PIK3CD (0.40) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL28029225 | 0.87 | PIK3CD (0.40) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL28028872 | 0.84 | TLR7 (0.49) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL28028882 | 0.84 | MTOR (0.59) | MTORUSP2LMNATP53MAPT | |
| SCHEMBL28029238 | 0.83 | MTOR (0.44) | MTORGRIN1GRIN2BUSP2LMNA | |
| SCHEMBL28948857 | 0.83 | GRIN1 (0.46) | MTORGRIN1GRIN2BUSP2LMNA | |
| SCHEMBL28029224 | 0.82 | MTOR (0.43) | MTORGRIN1GRIN2BUSP2LMNA | |
| SCHEMBL28029222 | 0.82 | CYP1A2 (0.54) | MTORGRIN1GRIN2BUSP2LMNA | |
| SCHEMBL28029216 | 0.82 | PIK3CD (0.49) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104870998-A | Inhibition of phosphorylation of PRAS40, GSK 3-beta or P70S6K1 as a marker of TOR kinase inhibitory activity | SIGNAL PHARM LLC | 2015-08-26 | — | — | CN | disclosed |