Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.49 |
| ▸ | MTOR | P42345 | 2/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28029216 | 0.90 | PIK3CD (0.49) | TLR7MTORPIK3CDPIK3CAPIK3CB | |
| SCHEMBL28028886 | 0.88 | PIK3CD (0.40) | TLR7MTORPIK3CDPIK3CAPIK3CB | |
| SCHEMBL28029225 | 0.88 | PIK3CD (0.40) | TLR7MTORPIK3CDPIK3CAPIK3CB | |
| SCHEMBL28028879 | 0.84 | PIK3CD (0.43) | MTORPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL28028896 | 0.82 | PIK3CD (0.49) | MTORPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL28029207 | 0.79 | PIK3CD (0.44) | PIK3CDPIK3CAPIK3CBPIK3CGALDH1A1 | |
| SCHEMBL28028868 | 0.78 | NUDT1 (0.52) | TLR7MTORALDH1A1MAPTMEN1 | |
| SCHEMBL28299576 | 0.78 | PIK3CD (0.48) | TLR7MTORPIK3CDPIK3CAPIK3CB | |
| SCHEMBL28028895 | 0.77 | PIK3CA (0.55) | MTORPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL28821909 | 0.77 | PIK3CD (0.48) | MTORPIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107976546-A | Inhibition of phosphorylation to TOR kinase inhibiting activities mark PRAS40, GSK3- β or P70S6K1 | 西格诺药品有限公司 | 2018-05-01 | — | — | CN | disclosed |
| CN-104870998-B | inhibition of phosphorylation of PRAS40, GSK3- β or P70S6K1 as a marker of TOR kinase inhibitory activity | 西格诺药品有限公司 | 2018-02-02 | — | — | CN | disclosed |
| CN-104870998-A | Inhibition of phosphorylation of PRAS40, GSK 3-beta or P70S6K1 as a marker of TOR kinase inhibitory activity | SIGNAL PHARM LLC | 2015-08-26 | — | — | CN | disclosed |