Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | RORC | P51449 | 2/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.43 |
| ▸ | TET3 | O43151 | 1/20 | 0.42 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.42 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.42 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.42 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.42 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.42 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31694033 | 1.00 | TSHR (0.52) | TSHRALOX15ATMTACR1KMT2A | |
| SCHEMBL30056366 | 0.93 | TSHR (0.47) | TSHRALOX15ATMTACR1KMT2A | |
| SCHEMBL27167101 | 0.93 | TSHR (0.47) | TSHRALOX15ATMTACR1KMT2A | |
| SCHEMBL19331220 | 0.89 | TSHR (0.48) | TSHRALOX15ATMTACR1KMT2A | |
| SCHEMBL972474 | 0.86 | TSHR (0.65) | TSHRALOX15ATMTACR1KMT2A | |
| SCHEMBL29135477 | 0.86 | TSHR (0.45) | TSHRALOX15ATMTACR1KMT2A | |
| SCHEMBL30775694 | 0.86 | TSHR (0.45) | TSHRALOX15ATMTACR1KMT2A | |
| SCHEMBL2577367 | 0.86 | TSHR (0.52) | TSHRALOX15ATMTACR1KMT2A | |
| SCHEMBL19690249 | 0.85 | TSHR (0.46) | TSHRALOX15ATMTACR1KMT2A | |
| SCHEMBL12988312 | 0.85 | TSHR (0.53) | TSHRALOX15ATMTACR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104876934-B | A kind of nitrogen heterocyclic ring phenylpiperidine compound and preparation method and application | 山东大学 | 2017-08-11 | — | — | CN | disclosed |
| CN-104876934-A | Nitrogen-containing heterocyclic phenyl piperidine compound as well as preparation method and application thereof | UNIV SHANDONG | 2015-09-02 | — | — | CN | disclosed |