Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 2/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | SRR | Q9GZT4 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27809578 | 0.86 | SCN9A (0.46) | SCN9ANPC1RAB9ACTSSCTSK | |
| SCHEMBL27502333 | 0.81 | SCN9A (0.57) | SCN9ANPC1MAPTRAB9ACTSS | |
| SCHEMBL28336154 | 0.80 | SCN9A (0.56) | SCN9ANPC1MAPTRAB9ACTSS | |
| SCHEMBL27438213 | 0.78 | SCN9A (0.54) | SCN9ANPC1MAPTRAB9ACTSS | |
| SCHEMBL28628480 | 0.78 | SCN9A (0.54) | SCN9ANPC1MAPTRAB9ACTSS | |
| SCHEMBL28529040 | 0.78 | SCN9A (0.53) | SCN9ANPC1MAPTRAB9ACTSL | |
| SCHEMBL28803147 | 0.76 | SCN9A (0.48) | SCN9AALDH1A1 | |
| SCHEMBL27669149 | 0.75 | SCN9A (0.51) | SCN9ANPC1MAPTRAB9ACTSL | |
| SCHEMBL14716956 | 0.73 | CTSK (0.49) | SCN9ANPC1MAPTRAB9ACTSS | |
| SCHEMBL28359858 | 0.73 | SCN9A (0.48) | SCN9ANPC1MAPTRAB9ACTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104797591-A | Fluorinated epoxyketone compounds and their use as proteasome inhibitors | SLASSI ABDELMALIK | 2015-07-22 | — | — | CN | disclosed |