Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16673038 | 0.88 | TSHR (0.67) | TSHRALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL17797782 | 0.84 | TSHR (0.66) | TSHRALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL16049266 | 0.79 | TSHR (0.59) | TSHRALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL17797867 | 0.79 | TSHR (0.59) | TSHRALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL8433421 | 0.79 | TSHR (0.59) | TSHRALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL17061429 | 0.78 | ESR1 (0.64) | TSHRALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL14409194 | 0.78 | TSHR (0.79) | TSHRALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL812415 | 0.78 | ALDH1A1 (0.55) | TSHRALDH1A1NPC1L3MBTL1TDP1 | |
| SCHEMBL14984028 | 0.77 | TSHR (0.68) | TSHRALDH1A1L3MBTL1TDP1TP53 | |
| SCHEMBL29860709 | 0.77 | TSHR (0.65) | TSHRALDH1A1L3MBTL1TDP1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102947285-B | Sulfonamide derivatives as BCL-2-selective apoptosis inducers for the treatment of cancer and immune diseases | ABBVIE (US) | 2015-08-26 | — | — | CN | disclosed |