Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | STAT1 | P42224 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28030136 | 0.84 | NFE2L2 (0.43) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL13740586 | 0.79 | NFE2L2 (0.45) | NFE2L2SMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL13832851 | 0.79 | NFE2L2 (0.45) | NFE2L2SMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL13740585 | 0.79 | NFE2L2 (0.45) | NFE2L2SMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL15608176 | 0.78 | NFE2L2 (0.46) | NFE2L2SMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL13738308 | 0.78 | NFE2L2 (0.46) | NFE2L2SMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL15626917 | 0.74 | HPGDS (0.42) | NFE2L2 | |
| SCHEMBL15608128 | 0.74 | HPGDS (0.42) | NFE2L2 | |
| SCHEMBL15608127 | 0.74 | HPGDS (0.42) | NFE2L2 | |
| SCHEMBL13738962 | 0.72 | NFE2L2 (0.45) | SLC6A3NFE2L2SMN1; SMN2KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104918615-B | The method for treating hepatopathy | 扎夫根股份有限公司 | 2018-10-12 | — | — | CN | disclosed |
| CN-103764641-B | The tricyclic compound of fractional saturation and preparation and application thereof | 扎夫根股份有限公司 | 2016-10-26 | — | — | CN | disclosed |
| CN-104918615-A | Methods of treating liver diseases | ZAFGEN INC | 2015-09-16 | — | — | CN | disclosed |