Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.44 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.42 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ESPL1 | Q14674 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.38 |
| ▸ | VCP | P55072 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17375034 | 0.87 | TTR (0.41) | CYP4F2CYP4A11ITGB1ITGA5ATM | |
| SCHEMBL28136377 | 0.87 | ITGB1 (0.40) | CYP4F2CYP4A11ITGB1ITGA5ATM | |
| SCHEMBL10719888 | 0.87 | SMN1; SMN2 (0.42) | CYP4F2CYP4A11ITGB1ITGA5ATM | |
| SCHEMBL17466056 | 0.86 | LMNA (0.40) | CYP4F2CYP4A11ITGB1ITGA5ATM | |
| SCHEMBL7215856 | 0.84 | HTT (0.41) | ATMTDP1ESPL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL16513277 | 0.83 | ATM (0.41) | ITGB1ITGA5ATMTDP1ESPL1 | |
| SCHEMBL23850947 | 0.83 | ALDH1A1 (0.44) | TDP1SMN1; SMN2ALDH1A1HTTLMNA | |
| SCHEMBL810412 | 0.80 | ALDH1A1 (0.43) | TDP1ESPL1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL512256 | 0.79 | ALDH1A1 (0.51) | ATMTDP1ESPL1ALDH1A1HIF1A | |
| SCHEMBL29804996 | 0.79 | ALDH1A1 (0.51) | ATMTDP1ESPL1ALDH1A1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108026052-B | 5-hydroxyalkyl benzimidazoles as mIDH1 inhibitors | 德国癌症研究公共权益基金会 | 2021-10-08 | — | — | CN | disclosed |
| CN-107810176-B | N-menthyl benzimidazoles as mIDH1 inhibitors | 德国癌症研究公共权益基金会 | 2020-10-16 | — | — | CN | disclosed |
| CN-110433162-A | It can be used as the dihydronaphthridine and related compound of the kinase inhibitor for treating proliferative disease | DECIPHERA PHARMACEUTICALS LLC | 2019-11-12 | — | — | CN | disclosed |
| CN-110403938-A | It can be used as the dihydronaphthridine and related compound of the kinase inhibitor for treating proliferative disease | DECIPHERA PHARMACEUTICALS LLC | 2019-11-05 | — | — | CN | disclosed |
| CN-104902895-B | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases | 德西费拉制药有限责任公司 | 2019-03-29 | — | — | CN | disclosed |
| CN-104902895-A | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases | FLYNN DANIEL L | 2015-09-09 | — | — | CN | disclosed |