Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL19817385 | 0.90 | CSNK2A1 (0.45) | CSNK2A1MAPTGAAALDH1A1NPC1 | |
| SCHEMBL6878797 | 0.81 | ALDH1A1 (0.62) | MAPTGAAALDH1A1NPC1RAB9A | |
| SCHEMBL29791239 | 0.81 | CTPS1 (0.57) | CSNK2A1MAPTGAAALDH1A1NPC1 | |
| SCHEMBL11143259 | 0.80 | CSNK2A1 (0.46) | CSNK2A1MAPTGAAALDH1A1NPC1 | |
| SCHEMBL17080205 | 0.79 | MAPT (0.47) | MAPTGAAALDH1A1NPC1RAB9A | |
| SCHEMBL11009364 | 0.78 | SMN1; SMN2 (0.69) | MAPTGAAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL11498389 | 0.77 | PDE5A (0.50) | CSNK2A1MAPTGAAALDH1A1NPC1 | |
| SCHEMBL5544014 | 0.77 | SMN1; SMN2 (0.57) | MAPTGAAALDH1A1NPC1RAB9A | |
| SCHEMBL25253732 | 0.76 | SMN1; SMN2 (0.53) | MAPTGAAALDH1A1NPC1RAB9A | |
| SCHEMBL29557286 | 0.76 | SIRT1 (0.53) | CSNK2A1GAAALDH1A1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104936954-A | compounds and methods of use thereof | AGIOS PHARMACEUTICALS INC | 2015-09-23 | — | — | CN | disclosed |