SCHEMBL28030875

SCHEMBL28030875

COc1ccccc1C[Si](C)(C)C

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 2/20 0.53
TAAR1 Q96RJ0 1/20 0.53
CHRM2 P08172 4/20 0.52
CHRM1 P11229 1/20 0.52
CA1 P00915 2/20 0.50
CA2 P00918 2/20 0.50
CA7 P43166 2/20 0.50
CA9 Q16790 2/20 0.50
ALDH1A1 P00352 2/20 0.50
GAA P10253 1/20 0.50
MAPT P10636 1/20 0.50
LMNA P02545 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
CA12 O43570 1/20 0.50
CA4 P22748 1/20 0.50
CA14 Q9ULX7 1/20 0.50
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47
SIGMAR1 Q99720 1/20 0.47
AOC3 Q16853 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18372464 0.83 IDO1 (0.50) IDO1TAAR1CHRM2CHRM1CA1
SCHEMBL27560101 0.82 IDO1 (0.48) IDO1TAAR1CHRM2CHRM1CA1
SCHEMBL1972978 0.81 IDO1 (0.52) IDO1TAAR1CHRM2CHRM1CA1
SCHEMBL1969650 0.81 ALDH1A1 (0.53) IDO1TAAR1CHRM2CHRM1CA1
SCHEMBL12445406 0.80 IDO1 (0.52) IDO1TAAR1CHRM2CHRM1CA1
SCHEMBL3949037 0.78 ESR1 (0.40) IDO1TAAR1MAPT
SCHEMBL7189414 0.78 IDO1 (0.48) IDO1TAAR1CHRM2CHRM1CA1
SCHEMBL3296809 0.77 IDO1 (0.61) IDO1TAAR1CHRM2CHRM1CA1
SCHEMBL28858018 0.77 TAAR1 (0.75) IDO1TAAR1CHRM2CHRM1CA1
SCHEMBL1974352 0.76 IDO1 (0.47) IDO1TAAR1CHRM2CHRM1CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104844427-B Synthetic method of benzyl ether compound 哈尔滨工业大学 2017-01-11 CN claimed
CN-104844427-A Synthetic method of benzyl ether compound HARBIN INST OF TECHNOLOGY 2015-08-19 CN claimed
CN-104844427-B Synthetic method of benzyl ether compound 哈尔滨工业大学 2017-01-11 CN disclosed
CN-104844427-A Synthetic method of benzyl ether compound HARBIN INST OF TECHNOLOGY 2015-08-19 CN disclosed