Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | CAPN1 | P07384 | 9/20 | 0.51 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | FCER2 | P06734 | 1/20 | 0.44 |
| ▸ | CCR1 | P32246 | 4/20 | 0.42 |
| ▸ | PYGL | P06737 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2800991 | 0.85 | CAPN1 (0.71) | ALDH1A1KDM4EHPGDMEN1MAPT | |
| SCHEMBL2800741 | 0.79 | CAPN1 (0.47) | CAPN1CCR1PYGL | |
| SCHEMBL2800282 | 0.79 | PYGL (0.47) | ALDH1A1KDM4EMAPTSMN1; SMN2CAPN1 | |
| SCHEMBL2799523 | 0.79 | CAPN1 (0.67) | ALDH1A1KDM4EHPGDMEN1MAPT | |
| SCHEMBL2802814 | 0.78 | CAPN1 (0.67) | ALDH1A1KDM4EHPGDMEN1MAPT | |
| SCHEMBL2801618 | 0.77 | CAPN1 (0.75) | CAPN1CCR1PYGL | |
| SCHEMBL11011887 | 0.74 | KDM4E (0.60) | ALDH1A1KDM4EHPGDMEN1MAPT | |
| SCHEMBL2800334 | 0.74 | CAPN1 (0.70) | ALDH1A1KDM4EHPGDMEN1MAPT | |
| SCHEMBL3713862 | 0.74 | CAPN1 (0.58) | CAPN1 | |
| SCHEMBL2797648 | 0.74 | CAPN1 (0.46) | CAPN1CCR1PYGL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9567325-B2 | Carboxamide compounds and their use as calpain inhibitors | AbbVie Deutschland GmbH & Co. KG (DE) | 2017-02-14 | — | — | US | disclosed |
| US-20150045394-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-02-12 | — | — | US | disclosed |
| US-8906941-B2 | Carboxamide compounds and their use as calpain inhibitors | ABBVIE INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-20100216844-A1 | Carboxamide compounds and their use as calpain inhibitors | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150045394-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | CAMK4, CAMK2A, CAMK2B | ALDH1A1 4565/4885KDM4E 624/4885HPGD 3070/4885 |
| US-20100216844-A1 | Carboxamide compounds and their use as calpain inhibitors | CAMK4, CAMK2A, CAMK2B | ALDH1A1 4543/4885KDM4E 577/4885HPGD 3120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.