Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 2/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | IL1B | P01584 | 1/20 | 0.39 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27936623 | 0.90 | DDB1 (0.51) | DDB1CRBNTNFIL1BIKZF3 | |
| SCHEMBL28822138 | 0.90 | HRH3 (0.39) | DDB1CRBNTNFIL1BIKZF3 | |
| SCHEMBL28030321 | 0.89 | PIK3CD (0.36) | DDB1CRBNTNFIL1BIKZF3 | |
| SCHEMBL28030943 | 0.88 | DDB1 (0.38) | DDB1CRBNTNFIL1BIKZF3 | |
| SCHEMBL27780651 | 0.87 | HTT (0.37) | DDB1CRBNTNFIL1BIKZF3 | |
| SCHEMBL28030923 | 0.85 | HDAC1 (0.38) | PIK3CDALDH1A1MAPK1KMT2ANPSR1 | |
| SCHEMBL25346369 | 0.84 | TNF (0.34) | DDB1CRBNTNFIL1BIKZF3 | |
| SCHEMBL27801155 | 0.84 | GAA (0.38) | DDB1CRBNTNFGAAALOX15 | |
| SCHEMBL25433270 | 0.83 | LMNA (0.33) | DDB1CRBNTNFIL1BIKZF3 | |
| SCHEMBL25345320 | 0.82 | TNF (0.35) | DDB1CRBNTNFIL1BIKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105017212-A | 5-substituted quinazolinone derivatives using as antineoplastic agent | CELGENE CORP | 2015-11-04 | — | — | CN | disclosed |
| CN-104910133-A | 5-SUBSTITUTED QUINAZOLINONE DERIVATIVES AS ANTITUMOR AGENTS | CELGENE CORP | 2015-09-16 | — | — | CN | disclosed |
| CN-104876908-A | 5-substituted quinazolinone derivatives as anti-cancer agents | CELGENE CORP | 2015-09-02 | — | — | CN | disclosed |